Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism

饮食、体力活动、体重指数和肺栓塞风险的前瞻性研究

• 批准号: 7502116
• 负责人: CARLOS A. CAMARGO
• 金额: $ 19.29万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7502116
• 关键词: Address; Adult; Affect; Age; Am 80; Antioxidants; Area; Blood; Blood Circulation; Blood Vessels; Body mass index; Cardiovascular system; Case Study; Clinical; Cohort Studies; Data; Data Collection; Deep Vein Thrombosis; Development; Diagnosis; Diet; Dietary Factors; Dietary Fiber; Disease; Elderly; Energy Intake; Environment; Epidemiologist; Exploratory/Developmental Grant; Female; Follow-Up Studies; Food; Foundations; Frequencies; Funding; Future; General Hospitals; Genes; Genetic Markers; Grant; Health Occupations; Health Professional; Hospitals; Image; Incidence; Individual; Intake; Intervention; Investigation; Laboratories; Lead; Learning; Life Style; Lung; Massachusetts; Measures; Medical Records; Nature; Normal Range; Nurses; Nurses' Health Study; Nutrient; Obesity; Omega-3 Fatty Acids; Outcome; Overweight; Participant; Pattern; Physical activity; Physicians; Population; Positioning Attribute; Prevention strategy; Primary Prevention; Prospective Studies; Public Health; Publications; Pulmonary Embolism; Questionnaires; Research; Research Personnel; Risk; Risk Factors; Role; Series; Swimming; Testing; Thinking; Thromboembolism; Tissues; Trans Fats; Trans Fatty Acids; Validation; Venous; Vitamin K; Walking; Woman; Work; cohort; data management; dietary supplements; follow-up; genetic analysis; men; modifiable risk; mortality; multidisciplinary; novel; nutrition; prospective; sedentary; tv watching

DESCRIPTION (provided by applicant): Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism Venous thromboembolism (VTE) represents a spectrum of disease that includes deep venous thrombosis (DVT) and pulmonary embolism (PE). Given the high incidence and sudden mortality associated with PE in the elderly, primary prevention is of vital importance. Unfortunately, our understanding of modifiable risk factors -- that could be used to guide the development of primary prevention strategies -- is very limited. The proposed study will address this information gap and bring together a multidisciplinary group of VTE clinical researchers and cardiovascular/nutrition epidemiologists at the Channing Laboratory, Brigham and Women's Hospital and Massachusetts General Hospital. We will use 2 large prospective observational cohort studies to examine the relationship between dietary factors, physical activity, body mass index (BMI) and risk of PE among elderly participants in the Nurses' Health Study (NHS) and the Health Professionals' Follow-Up Study (HPFS), using data from 1985 to 2002. NHS is an ongoing prospective cohort study of 121,700 female nurses, age 50-55 in 1986 (approx. 650 PE cases). HPFS is an ongoing prospective cohort study of 51,529 men in health professions age 40-75 in 1986 (approx. 350 PE cases). We will address the following questions: Are major dietary patterns (Prudent vs. Western), and specific dietary factors (i.e., omega-3 fatty acids, trans fats, dietary fiber, antioxidants, Vitamin K-containing foods) associated with different risks of PE? Is the risk of PE modified by increasing levels of physical activity? Within the normal range, is BMI positively associated with PE? Exposure information was gathered by validated measures, including the Semiquantitative Food Frequency Questionnaire, the Physical Activity Questionnaire, and an extensive list of covariates collected biannually in NHS and HPFS. We will validate reported cases of PE using supplementary questionnaires and medical records; such data collection was initiated two decades ago and the current grant would fund the completion of outcome validation, data management, and testing of the hypotheses listed above. Statistical power is >80% for all of proposed aims. The project would lay the foundation for future work on genetic markers of PE risk in these large cohort studies. We hope to identify and quantify risk factors for PE that lead to public health interventions that effectively decrease the incidence of VTE in the elderly population. Project Narrative: Venous thromboembolism is a common and deadly disease, especially among the elderly. We propose to study >150,000 adults in two large prospective cohort studies (the Nurses' Health Study and Health Professionals' Follow-up Study) to learn how modifiable risk factors related to diet, physical activity, and body mass index affect the risk of pulmonary embolism. We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population.

描述（由申请人提供）：饮食、身体活动、BMI和肺栓塞风险的前瞻性研究静脉血栓栓塞（VTE）代表了包括深静脉血栓形成（DVT）和肺栓塞（PE）在内的一系列疾病。鉴于老年人PE的高发病率和猝死率，一级预防至关重要。不幸的是，我们对可用于指导初级预防战略发展的可改变风险因素的理解非常有限。拟议的研究将解决这一信息差距，并汇集多学科小组VTE临床研究人员和心血管/营养流行病学家在钱宁实验室，布莱根妇女医院和马萨诸塞州总医院。我们将使用两项大型前瞻性观察队列研究来检查护士健康研究（NHS）和卫生专业人员随访研究（HPFS）中老年参与者的饮食因素、身体活动、体重指数（BMI）和PE风险之间的关系，使用1985年至2002年的数据。NHS是一项正在进行的前瞻性队列研究，对121,700名年龄在50-55岁的女护士进行了研究。650个PE箱)。HPFS是一项正在进行的前瞻性队列研究，在1986年对51,529名年龄在40-75岁之间的卫生专业男性进行了研究。350个PE箱)。我们将回答以下问题：

项目成果

Physical inactivity and idiopathic pulmonary embolism in women: prospective study.

• DOI: 10.1136/bmj.d3867
• 发表时间: 2011-07-04
• 期刊: BMJ (Clinical research ed.)
• 作者: Kabrhel C;Varraso R;Goldhaber SZ;Rimm E;Camargo CA Jr
• 通讯作者: Camargo CA Jr

Prospective study of BMI and the risk of pulmonary embolism in women.

• DOI: 10.1038/oby.2009.92
• 发表时间: 2009-11
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Kabrhel, Christopher;Varraso, Raphaelle;Goldhaber, Samuel Z.;Rimm, Eric B.;Camargo, Carlos A.
• 通讯作者: Camargo, Carlos A.