A Preservation and Packaging Platform for Cell and Tissue Based Therapies

用于细胞和组织疗法的保存和包装平台

• 批准号: TS/G000263/1
• 负责人: David John Williams
• 金额: $ 23.95万
• 依托单位: Loughborough University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=TS%2FG000263%2F1
• 关键词: Preservation; Packaging; Platform; Cell; Tissue

This project aims to create a preservation and packaging platform for cell and tissue based therapies, allowing UK companies to reach the European, North American and other global markets. Traditionally, preservation, storage and transportation solutions for biological entities, mostly protein-based, have involved lyophilisation (freeze drying) and/or cryopreservation. However, living cells constitute an essential part of cell therapy applications and there is a real and urgent need for packaging solutions that preserve cell viability and function post transport, and provide ease-of-use to the end-user in clinic. Validatable packaging platforms that allow improved preservation and shelf life of living products will give UK businesses the capability to reach world markets from UK sites and maximise their share of the global value chain. This project will demonstrate key components of a packaging and shipping platform for human cell and tissue based therapies.

该项目旨在为细胞和组织疗法创建一个保存和包装平台，使英国公司能够进入欧洲、北美和其他全球市场。传统上，生物实体（主要是蛋白质）的保存、储存和运输解决方案涉及冻干（冷冻干燥）和/或冷冻保存。然而，活细胞是细胞治疗应用的重要组成部分，因此迫切需要一种包装解决方案，以保持细胞在运输后的活力和功能，并为临床最终用户提供易用性。可验证的包装平台可以改善活产品的保存和保质期，这将使英国企业能够从英国网站进入世界市场，并最大限度地提高其在全球价值链中的份额。该项目将展示用于人类细胞和组织治疗的包装和运输平台的关键组件。

项目成果

Scale up and Manufacturing of Cell-Based Therapies

细胞疗法的规模化和制造

• 作者: David John Williams (Author)

6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore

第六届世界生物力学大会（WCB 2010）。

• DOI: 10.1007/978-3-642-14515-5_289
• 发表时间: 2010
• 作者: Nikolaev N

Effect of Cold Storage and Mechnical Vibration on Human Mesenchymal Stem Cell Therapeutic Products Transported in Suspension

冷藏和机械振动对悬浮运输的人间充质干细胞治疗产品的影响

• 作者: Nikolay Nikolaev (Author)

Effects of Dynamical Mechanical Forces on Human Mesenchymal Stem Cell Therapy Products

动态机械力对人类间充质干细胞治疗产品的影响

• 作者: David John Williams (Author)