The Audible Human Project

有声人类计划

• 批准号: 7493989
• 负责人: THOMAS J ROYSTON
• 金额: $ 7.25万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-05 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493989
• 关键词: 3-Dimensional; Acoustics; Advanced Development; Anatomy; Animals; Auscultation; Behavior; Biological; Boundary Elements; Cardiovascular system; Chicago; Code; Complex; Computer Simulation; Coupling; Data Set; Development; Diagnostic; Diagnostic Procedure; Education; Elements; Environment; Feedback; Female; Future; Generations; Goals; Hearing; Home environment; Human; Human body; Illinois; Image; Imaging technology; Intestines; Journals; Laboratories; Life; Lung; Magnetic Resonance Imaging; Measurement; Medical Device Designs; Medical Education; Medical Imaging; Medicine; Methodology; Methods; Metric; Modality; Modeling; Monitor; Operative Surgical Procedures; Oral cavity; Outpatients; Pathology; Patients; Percussion; Physicians; Positioning Attribute; Production; Property; Research; Research Personnel; Resources; Respiratory Sounds; Simulate; Skin; Source; Stethoscopes; Students; Surface; System; Tactile; Technology; Time; Tissues; Trees; Ultrasonics; United States National Library of Medicine; Universities; Visible Human Project; Vision; Visualization software; base; design; emergency service responder; experience; glottis; haptics; human male; human subject; improved; male; models and simulation; pressure; sensor; simulation; skills; soft tissue; sound; tool; transmission process; virtual reality

DESCRIPTION (provided by applicant): The Visible Human Project (VHP) of the National Library of Medicine has catalyzed the development of advanced visualization software that has aided in anatomy education and has been an invaluable resource to biomedical researchers. It has aided in the development of numerous technologies, with applications spanning from improving imaging technology to simulating surgical procedures. Our long-term goal is to develop a comparable "Audible Human Project" (AHP). This would accurately simulate the production, transmission and noninvasive measurement (for example using stethoscopes) of naturally-occurring sounds associated with cardiovascular, pulmonary and gastro-intestinal function. It would also model externally introduced sounds, for example via percussion at the skin surface. Such a comprehensive tool would have a significant impact on medical education and research. It could catalyze the development of new inexpensive, portable auscultative methods, as well as more advanced multimode acoustic imaging modalities. From an educational perspective, recent studies have emphasized the continued importance of skilled auscultation in medicine and the fact that this skill is in decline among younger physicians. The AHP could help provide a more effective educational experience. A student would not just listen to audio recordings. He or she would be able to interactively vary anatomy and pathology, as well as sensor position, type and contact pressure, so as to hear, "see" and "feel" (if integrated within a haptic environment) the results and associate them with quantifiable metrics. The specific aim of this R03 application is to develop and experimentally validate an upper torso acoustic model focused on the pulmonary system. This model will simulate breath sound generation, transmission and measurement via contact sensors placed on the torso surface. It will also simulate the transmission and measurement of externally introduced sound via the airways or via percussion of the torso surface. Subject- specific torso acoustic models will be generated for 3 healthy human subjects (males) based on x-ray CT images. Detailed acoustic measurements on these same subjects will then be used to validate the simulation model. Once validated this modeling approach will be used to develop an acoustic torso model for the visible human male of the VHP available via the NLM. This torso component of a "audible human male" will then be made available to all via a webserver maintained in the PI's laboratory at the University of Illinois at Chicago. To accomplish this, a boundary element (BE) based computational code that simulates sound propagation in biological tissues, including the lung airways and parenchymal tissue, will be enhanced by incorporating lung sound source generation and coupling it to a finite element model of the surrounding ribcage and soft tissue region, and by including coupling to skin-mounted sensors, like stethoscopes, which can have their own complex dynamic behavior.

描述（由申请人提供）：美国国家医学图书馆的可视人体项目（VHP）促进了高级可视化软件的发展，该软件有助于解剖学教育，并已成为生物医学研究人员的宝贵资源。它帮助开发了许多技术，应用范围从改进成像技术到模拟外科手术。我们的长期目标是开发一个类似的“可听人类项目”（AHP）。这将准确地模拟与心血管、肺和胃肠功能相关的自然发生的声音的产生、传输和非侵入性测量（例如使用听诊器）。它还可以模拟外部引入的声音，例如通过在皮肤表面的敲击。这样一个全面的工具将对医学教育和研究产生重大影响。它可以促进新的廉价，便携式听诊方法的发展，以及更先进的多模式声学成像模式。从教育的角度来看，最近的研究强调了熟练的听诊在医学中的持续重要性，以及这种技能在年轻医生中正在下降的事实。AHP可以帮助提供更有效的教育经验。一个学生不会只听录音。他或她将能够交互地改变解剖结构和病理学，以及传感器位置、类型和接触压力，以便听到、“看到”和“感觉到”（如果集成在触觉环境中）结果，并将它们与可量化的度量相关联。该R03应用程序的具体目标是开发并通过实验验证上躯干声学模型，重点关注肺部系统。该模型将通过放置在躯干表面的接触式传感器模拟呼吸声的产生、传输和测量。它还将模拟通过气道或通过敲击躯干表面的外部引入声音的传输和测量。将基于X射线CT图像为3名健康人类受试者（男性）生成受试者特定躯干声学模型。然后，将使用对这些相同对象的详细声学测量来验证模拟模型。一旦确认，该建模方法将用于开发通过NLM可用的VHP的可见人类男性的声学躯干模型。然后，通过位于芝加哥的伊利诺伊大学PI实验室中维护的网络服务器，所有人都可以使用“可听见的人类男性”的躯干组件。为了实现这一点，将通过结合肺声源生成并将其耦合到周围胸腔和软组织区域的有限元模型，以及通过包括耦合到皮肤安装的传感器（如听诊器）来增强模拟生物组织（包括肺气道和实质组织）中的声音传播的基于边界元件（BE）的计算代码，所述传感器可以具有它们自己的复杂动态行为。