NEW PARADIGMS IN TISSUE VIBRATION FOR DIAGNOSTIC METHODS

描述(改编自申请人的摘要)：主要目标 这项研究是为了发展新的理论认识范式和 生物组织在低听声区振动的实验测量 频率范围。需要强调的是，这项研究并不是为了发展 与超声波或其他现有成像方法竞争的新成像方法 方法：研究方法。取而代之的是，研究人员提议对 生物组织振动可以提供关于 仅仅通过“结构”成像可能无法达到的“功能”。 了解组织的振动行为有望有助于 开发全新的技术，提供高灵敏度和 专用性、低成本和更大的可移植性。例如，考虑 一种手持式廉价设备的可能性，它可以在几秒钟内使用 可听的声音，可以无痛地、准确地诊断 肺部塌陷、肠穿孔或颈动脉闭塞的严重程度。这 低可听频率范围是有意义的，因为 心血管、肺、胃肠和肌肉骨骼系统 是由低于1千赫的光谱含量主导的。此外，“活动” 诊断方法，如声弹成像，从外部介绍 在低可听频率范围内的振动能量，并测量由此产生的 组织反应。为了理性地探索被测量的意义 复杂的声音信号，关键是要知道 中间组织(如皮肤、筋膜、脂肪)在调节 产生和检测之间的信号。尽管……富有 出现在低频范围内的信息可能具有很好的诊断作用 低可听频率波振动的价值、基本方面 人们对生物组织知之甚少。在几千赫以下，都是压缩， 剪切、表面和层间面波的传播可以是显著的 高度依赖于组织特性。猪瘟的初步研究近况 这个团队的成员对这种振动有了更好的理解- 声学问题。这项研究提出了创新实施 理论、计算和实验技术，目前用于 非生物振动体裁，以进一步提高我们对LOW的理解 在复杂的生物条件下频率组织振动才能产蛋 为开发新的诊断方法奠定了基础。它是 期待组织振动耦合的新理论范式 与创新的测量方法最终可以提高诊断 对疾病的能力将在至少六个人的范围内 不同的NIH研究所：NCI、NHLBI、NIA、NIAMS、NIDDK和NINDS。

DESCRIPTION (Adapted from the applicant's abstract): The primary objective of this research is to develop new paradigms of theoretical understanding and experimental measurement of vibration of biological tissue in the low audible frequency range. It is emphasized that this research is not meant to develop new imaging methodologies to compete with ultrasound or other existing methods. Instead, the investigators are proposing a fundamental study of biological tissue vibration that could provide additional information about "function" that may not be accessible by mere "structural" imaging. Understanding tissue vibratory behavior is expected to contribute to the development of entirely new techniques offering high sensitivity and specificity, reduced cost and greater portability. For example, consider the possibility of a hand-held inexpensive device that, in a few seconds using audible sound, could painlessly and accurately diagnose conditions such as a collapsed lung, a perforated gut, or severity of a carotid occlusion. This low audible frequency range is of interest since internal vibratory sources of the cardiovascular, pulmonary, gastrointestinal and musculoskeletal systems are dominated by spectral content below 1 kHz. Additionally, " active" diagnostic methods, such as sonoelastic imaging, externally introduce vibratory energy in the low audible frequency range and measure the resulting tissue response. In order to rationally explore the meaning of the measured complex acoustic signals, it is critical to know the effect that the intervening tissue (for example, skin, fascia, fat) has in modulating the signal between generation and detection. In spite of the wealth of information present in the low-frequency range that can be of great diagnostic value, fundamental aspects of low audible frequency wave vibration in biological tissue are poorly understood. Below a few kHz, both compression, shear, surface and interlayer surface wave propagation can be significant and highly dependent on tissue properties. Recent preliminary research of the PI and members of this team has led to an improved understanding of this vibro- acoustic problem. This study proposes the innovative implementation of theoretical, computational and experimental techniques, currently used in nonbiological vibration genres, to further enhance our understanding of low frequency tissue vibration in a complex biological condition in order to lay the groundwork for the development of new diagnostic methods. It is anticipated that the new theoretical paradigms in tissue vibration coupled with innovative measurement methods could eventually improve the diagnostic capabilities for diseases that would be within the domain of at least six different NIH institutes: NCI, NHLBI, NIA, NIAMS, NIDDK, and NINDS.