PROJECT 1: FUNCTIONAL ANATOMY OF NEUROCOGNITIVE DETERIORATION IN SCHIZOPHRENIA

项目 1：精神分裂症神经认知恶化的功能解剖学

• 批准号: 7279677
• 负责人: LARRY SEIDMAN
• 金额: $ 43.96万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7279677
• 关键词: Anatomy; Anterior; Applied Research; Attention; Back; Belief; Biological Markers; Brain; Brain-Derived Neurotrophic Factor; Broca' s area; COMT gene; Catechol O-Methyltransferase; Chronic; Chronic Schizophrenia; Data; Depth; Deterioration; Development; Disease; Early Intervention; Event; Evolution; Family; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Genetic Variation; Goals; Gray unit of radiation dose; Hippocampus (Brain); Hydrocortisone; Impairment; Incipient Schizophrenia; Insula of Reil; Language; Lateral; Life; Maps; Measures; Memory; NR3C1 gene; National Institute of Mental Health; Neocortex; Neuregulins; Neuroanatomy; Neurobiology; Neurocognition; Neurocognitive; Neuropsychology; Parahippocampal Gyrus; Parietal Lobe; Patients; Persons; Phase; Prefrontal Cortex; Prevention; Prevention approach; Process; Psychopathology; Psychotic Disorders; Range; Rate; Recording of previous events; Request for Applications; Risk; Schizophrenia; Short-Term Memory; Staging; Stress; Structure; Superior temporal gyrus; Symptoms; Time; Trauma; Ventricular; Work; brain volume; cingulate cortex; cognitive neuroscience; design; executive function; follow-up; frontal lobe; functional outcomes; gray matter; indexing; interest; neuroimaging; neuropsychological; preconditioning; processing speed; relating to nervous system; response; size; therapy development; white matter

This application requests five years of support to establish a Project on "Functional Neuroanatomy of Neurocognitive Deterioration in Schizophrenia". This project, utilizing neuropsychological and neuroimaging measures is a part of an NIMH Center for Intervention Development and Applied Research ("CIDAR"), entitled 'Vulnerability to Progression in Schizophrenia". Utilizing our expertise in neuropsychology, cognitive neuroscience and structural neuroimaging, we expect to map the functional neuroanatomy of neurocognitive deterioration in the prodromal period and develop biomarkers for predicting conversion to psychosis, and further deterioration. Our focus on executive control reflects the belief that this is the central mechanism associated with growing cortical gray matter loss over time in schizophrenia. We will perform functional and structural neuroimaging on 75 persons considered to be "prodromal" for schizophrenia (24 of whom are expected to convert) and 75 matched controls. Each subject will be assessed at baseline and one year follow-up. We believe that in-depth understanding of the functional neuroanatomy of the prodromal period is a necessary precondition for better treatment, and possible prevention of the illness.

该申请要求五年的支持，以建立一个项目“功能神经解剖学的 精神分裂症中的神经认知恶化”。这个项目利用神经心理学和神经影像学 措施是NIMH干预发展和应用研究中心（“CIDAR”）的一部分， 题为“精神分裂症患者的发展脆弱性”利用我们在神经心理学，认知 神经科学和结构神经影像学，我们希望映射神经认知的功能神经解剖学 前驱期的恶化，并开发用于预测转化为精神病的生物标志物，以及 进一步恶化。我们对执行控制的关注反映了这样一种信念，即这是核心机制 与精神分裂症患者随着时间的推移皮质灰质丢失有关。我们将履行职能， 对75名被认为是精神分裂症“前驱”的人进行了结构神经成像（其中24人是 预期转化）和75个匹配对照。每例受试者将在基线和1年时接受评估 随访我们认为，深入了解前驱期的功能神经解剖学是 这是更好地治疗和预防疾病的必要先决条件。