PROJECT 1: FUNCTIONAL ANATOMY OF NEUROCOGNITIVE DETERIORATION IN SCHIZOPHRENIA

项目 1：精神分裂症神经认知恶化的功能解剖学

• 批准号: 8318783
• 负责人: LARRY SEIDMAN
• 金额: $ 24.6万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318783
• 关键词: Anatomy; Anterior; Applied Research; Attention; Back; Belief; Biological Markers; Brain; Brain-Derived Neurotrophic Factor; Broca' s area; Chronic; Chronic Schizophrenia; Data; Deterioration; Development; Disease; Early treatment; Event; Evolution; Family; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Genetic Variation; Goals; Hippocampus (Brain); Hydrocortisone; Impairment; Incipient Schizophrenia; Insula of Reil; Language; Lateral; Life; Maps; Measures; Memory; NR3C1 gene; National Institute of Mental Health; Neocortex; Neuregulins; Neuroanatomy; Neurobiology; Neurocognition; Neurocognitive; Neuropsychology; Parahippocampal Gyrus; Parietal Lobe; Patients; Persons; Phase; Prefrontal Cortex; Prevention; Prevention approach; Process; Psychopathology; Psychotic Disorders; Recording of previous events; Request for Applications; Risk; Schizophrenia; Short-Term Memory; Staging; Stress; Structure; Superior temporal gyrus; Symptoms; Time; Trauma; Ventricular; Work; brain volume; cingulate cortex; cognitive neuroscience; design; executive function; follow-up; frontal lobe; functional outcomes; gray matter; indexing; interest; neuroimaging; neuropsychological; preconditioning; processing speed; relating to nervous system; research and development; response; therapy development; white matter

This application requests five years of support to establish a Project on "Functional Neuroanatomy of Neurocognitive Deterioration in Schizophrenia". This project, utilizing neuropsychological and neuroimaging measures is a part of an NIMH Center for Intervention Development and Applied Research ("CIDAR"), entitled 'Vulnerability to Progression in Schizophrenia". Utilizing our expertise in neuropsychology, cognitive neuroscience and structural neuroimaging, we expect to map the functional neuroanatomy of neurocognitive deterioration in the prodromal period and develop biomarkers for predicting conversion to psychosis, and further deterioration. Our focus on executive control reflects the belief that this is the central mechanism associated with growing cortical gray matter loss over time in schizophrenia. We will perform functional and structural neuroimaging on 75 persons considered to be "prodromal" for schizophrenia (24 of whom are expected to convert) and 75 matched controls. Each subject will be assessed at baseline and one year follow-up. We believe that in-depth understanding of the functional neuroanatomy of the prodromal period is a necessary precondition for better treatment, and possible prevention of the illness.

该申请要求五年的支持，以建立“功能神经解剖学”项目 精神分裂症的神经认知恶化”。该项目利用神经心理学和神经影像学 措施是 NIMH 干预开发和应用研究中心 (“CIDAR”) 的一部分， 题为“精神分裂症进展的脆弱性”。利用我们在神经心理学、认知学方面的专业知识 神经科学和结构神经影像，我们期望绘制神经认知的功能神经解剖图 前驱期恶化并开发预测转化为精神病的生物标志物，以及 进一步恶化。我们对执行控制的关注反映了这样的信念：这是核心机制 与精神分裂症患者随着时间的推移皮质灰质损失的增加有关。我们将执行功能性和 对 75 名被认为是精神分裂症“前驱期”的人进行了结构神经影像检查（其中 24 人是 预计转换）和 75 个匹配的控件。每个科目都将在基线和一年内进行评估 后续行动。我们认为，深入了解前驱期的功能神经解剖学是 更好治疗和可能预防疾病的必要先决条件。