Special Scientific Procedures ( Longitudinal Assessment ) Core

双相情感障碍是一种动态疾病，其症状和综合征表现不断变化， 混淆神经影像学结果的解释以及治疗反应。这种疾病的特征 随着病情的发展，需要对患者进行检查，以澄清相互作用 临床反应和情感状态之间的联系仔细的纵向评估 和主题保留是BITREC及其拟议项目成功的关键因素。的 纵向评估核心（LAC）将满足这一需求，是十多年来 年轻的双相情感障碍患者。具体来说，我们的纵向研究经验是 这体现在一些大型长期项目的成功上。我们以前和正在进行的项目 为双相情感障碍的纵向研究提供了基础设施，从而制定了LAC。 拉丁美洲和加勒比区域中心将与《业务活动计划》中所述的其他BITREC核心和项目充分整合。 计划Paul Keck博士，精神病学和药理学教授， 精神病学系将指导LAC。他将负责总体核心职能， 监督基础设施建设。他将在几位临床医生和工作人员的协助下， 对入组BITREC的受试者进行临床护理和持续评估。法援会将举行员工会议， 每隔一周，以确保达到征聘基准，并审查已 开发新的情感发作或症状，以确定他们是否有资格获得额外的 BITREC项目。将制定标准作业程序，以最大限度地提高效率， 目标和基准。涉及日常核心职能的大多数决定将由 在凯克医生的指导下进行这些决定将由BITREC指导委员会指导并向其报告。 以马克思此外，凯克博士将被纳入BITREC的整体行政结构 在指导委员会任职建立这一结构后，拉加经委会将能够履行其 主要功能是：1）为积极参与BITREC项目的受试者提供治疗; 2)为入组BITREC的受试者提供持续的临床评价和出色的临床护理 3）确定符合新BITREC项目标准的受试者。通过关注和 通过跨项目管理主题，LAC有助于进一步整合BITREC的各个组成部分， 确保一个有凝聚力和有效的研究中心。

Bipolar disorder is a dynamic illness with constantly changing symptom and syndrome presentations that confound interpretation of neuroimaging findings, as well as treatment response. This feature of the illness raises the need to examine patients as the condition evolves over time in order to clarify interactions between neuroimaging measures, clinical response and affective state. Careful longitudinal assessments and subject retention are critical elements to the success of the BITREC and its proposed projects. The Longitudinal Assessment Core (LAC) will serve this need and is a direct extension of over a decade of experience following young bipolar patients. Specifically, our experience with longitudinal studies is demonstrated by the success of a number of large, long-term projects. Our previous and ongoing projects provide an infrastructure for the longitudinal study of bipolar disorder from which the LAC will be developed. The LAC will be fully integrated with the other BITREC cores and projects as described in the Operational Plan. Dr. Paul Keck, Professor of Psychiatry and Pharmacology and Vice-Chair for Research in the Department of Psychiatry will direct the LAC. He will be responsible for overall core function and for overseeing infrastructure development. He will be assisted by several clinicians and staff to provide excellent clinical care and ongoing assessments to subjects enrolled in the BITREC. The LAC will hold staff meetings every other week to ensure that recruitment benchmarks are being met and to review subjects who have developed new affective episodes or symptoms in order to determine whether they qualify for additional BITREC projects. Standard operating procedures will be developed to maximize efficiency and meet objectives and benchmarks. Most decisions involving daily core function will be made by the personnel of the core under the direction of Dr. Keck. These decisions will be guided by and reported to the BITREC Steering Committee. Additionally, Dr. Keck will be integrated within the overall administrative structure of the BITREC by serving on the Steering Committee. With this structure established the LAC will be able to meet its primary functions which are: 1) to provide treatment to subjects actively participating in BITREC projects; 2) to provide ongoing clinical evaluations and excellent clinical care to subjects enrolled in the BITREC between projects; and 3) to identify subjects who meet criteria for a new BITREC project. By following and managing subjects across project, the LAC helps to further integrate the various components of the BITREC, assuring a cohesive and effective research center.