U of Cincinnati Bipolar Disorder Imaging & Treatment Research Center (BITREC)

辛辛那提大学双相情感障碍成像

• 批准号: 8099711
• 负责人: STEPHEN M STRAKOWSKI
• 金额: $ 179.39万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8099711
• 关键词: Cincinnati; Bipolar; Disorder; Imaging; Treatment

Bipolar disorder is a dynamic, progressive illness in which treatment decisions are made empirically. Neuroimaging has helped to define neurophysiological models of bipolar disorder that offer the promise of improving treatment assignment by identifying markers and predictors of treatment response and disease progression. We propose the UC Bipolar Disorder Imaging & Treatment Research Center (BITREC) to meet this promise. The overall hypothesis and organizing theme guiding this center is that bipolar disorder results from dysfunctional brain metabolism within specific brain systems (i.e., the anterior limbic network) that can be monitored in response to treatments using magnetic resonance imaging (MRI) and spectroscopy (MRS). In this center, we will integrate MRI and MRS with outcome measures and treatment trials in order to develop specific neurophysiological models of treatment response early in the course of bipolar disorder. These models will provide the means to identify markers and predictors of treatment response to individualize medication prescription, thereby minimizing affective recurrences, preventing disease progression, and improving long-term course of illness. In order to achieve our goals, we will integrate our extensive prior experience and current resources to create specific research and administrative cores; these cores will be used to establish the BITREC infrastructure. With this infrastructure in place, we will recruit a large sample of bipolar patients early in the course of illness (prior to significant illness progression), as well as a cohort of at-risk subjects (adolescents without bipolar disorder, but with bipolar parents). These subjects will be asked to participate in specific projects integrating MRI, MRS, treatment and clinical outcome in order to refine existing models of the neurophysiology of bipolar disorder. We will use these models in order to identify specific neurophysiological markers of treatment response in order to clarify the effects that different medications have on bipolar neurophysiology. We will then use these markers to develop specific neurophysiological predictors of treatment response and illness progression in bipolar disorder. Finally, we will apply these models to at-risk patients (prior to developing a first manic episode) in order to prevent or delay the onset of bipolar disorder.

双相情感障碍是一种动态的、进行性的疾病，治疗决策是根据经验做出的。 神经影像学有助于定义双相情感障碍的神经生理学模型，该模型有望通过识别治疗反应和疾病进展的标记物和预测因子来改善治疗分配。我们提议成立加州大学双相情感障碍影像与治疗研究中心 (BITREC) 来实现这一承诺。指导该中心的总体假设和组织主题是，双相情感障碍是由特定大脑系统（即前边缘网络）内的脑代谢功能障碍引起的， 使用磁共振成像 (MRI) 和光谱学 (MRS) 监测治疗反应。 在该中心，我们将把 MRI 和 MRS 与结果测量和治疗试验结合起来，以便开发双相情感障碍早期治疗反应的特定神经生理学模型。 这些模型将提供识别个体化药物处方治疗反应的标记物和预测因子的方法，从而最大限度地减少情感复发、预防疾病进展并改善长期病程。为了实现我们的目标，我们将整合我们丰富的先前经验和现有资源，创建具体的研究和管理核心；这些核心将用于建立 BITREC 基础设施。有了这个基础设施，我们将在病程早期（在重大疾病进展之前）招募大量双相情感障碍患者样本，以及一组高危受试者（没有双相情感障碍但有双相情感障碍父母的青少年）。这些受试者将被要求参与整合 MRI、MRS、治疗和临床结果的具体项目，以完善双相情感障碍神经生理学的现有模型。我们将使用这些模型来 确定治疗反应的特定神经生理学标志物，以阐明不同药物对双相神经生理学的影响。然后，我们将使用这些标记物来开发双相情感障碍治疗反应和疾病进展的特定神经生理学预测因子。最后，我们将这些模型应用于高危患者（在第一次躁狂发作之前），以预防或延迟双相情感障碍的发作。

项目成果

Brain functional activation and first mood episode in youth at risk for bipolar disorder.

有双相情感障碍风险的青少年的大脑功能激活和首次情绪发作。

• DOI: 10.1016/j.jad.2023.03.025
• 发表时间: 2023
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Nery,FabianoG;Welge,JeffreyA;Fleck,David;Weber,Wade;Patino,LRodrigo;Strawn,JeffreyR;Adler,CalebM;Strakowski,StephenM;DelBello,MelissaP
• 通讯作者: DelBello,MelissaP

Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study.

• DOI: 10.1590/1516-4446-2019-0802
• 发表时间: 2020-09
• 期刊: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
• 作者: Nery FG;Wilson AR;Schneider MR;Strawn JR;Patino LR;McNamara RK;Adler CM;Strakowski SM;DelBello MP
• 通讯作者: DelBello MP

fMRI brain activation changes following treatment of a first bipolar manic episode.

• DOI: 10.1111/bdi.12426
• 发表时间: 2016-09
• 期刊: Bipolar disorders
• 影响因子: 5.4
• 作者: Strakowski SM;Fleck DE;Welge J;Eliassen JC;Norris M;Durling M;Komoroski RA;Chu WJ;Weber W;Dudley JA;Blom TJ;Stover A;Klein C;Strawn JR;DelBello MP;Lee JH;Adler CM
• 通讯作者: Adler CM

The complexities of depression.

抑郁症的复杂性。

• DOI: 10.1007/s11920-012-0330-7
• 发表时间: 2012
• 期刊: Current psychiatry reports
• 影响因子: 6.7
• 作者: Strakowski,StephenM

Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment.

第一次躁狂发作期间与杏仁核和尾状的前扣带回的功能连通性的变化区分了双极年轻人，他们在治疗后未屈服的年轻人。

• DOI: 10.1111/bdi.13025
• 发表时间: 2021-08
• 期刊: Bipolar disorders
• 影响因子: 5.4
• 作者: Lippard ETC;Weber W;Welge J;Adler CM;Fleck DE;Almeida J;DelBello MP;Strakowski SM
• 通讯作者: Strakowski SM