Role of Lung Inflammation in Th2 Priming

肺部炎症在 Th2 启动中的作用

基本信息

批准号：
7640840
负责人：
SUZANNE L. CASSEL
金额：
$ 12.1万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-01 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7640840
关键词：
Affect Allergens Allergic Allergy and Immunology Antigens Asthma Award B-Lymphocytes Breathing Bronchial Hyperreactivity CD4 Positive T Lymphocytes Cells Chronic Clinical Clinical Data Clinical Immunology Complex Data Dendritic Cells Developed Countries Developing Countries Development Disease Doctor of Medicine Effector Cell Epidemic Extrinsic asthma Fellowship Goblet Cells Hyperplasia Hypersensitivity IL4 gene IgE Immune Immune response Immune system Immunobiology Individual Inflammation Institutes Interleukin-13 Interleukin-4 Internal Medicine Investigation Laboratories Lead Learning Lung Lung Inflammation Mediating Mentors Modeling Morbidity - disease rate Mucous body substance Mus Pathogenesis Patient Care Patients Peptides Play Pneumonia Population Postdoctoral Fellow Principal Investigator Process Production Program Development Reaction Research Research Personnel Residencies Resources Risk Role Signal Transduction Students Syndrome T-Cell Activation T-Lymphocyte Testing Th2 Cells Time Toll-like receptors Training Training Programs Universities airborne allergen airway inflammation career cell growth cell type cytokine eosinophil mast cell medical schools mortality prevent professor programs response skills

项目摘要

DESCRIPTION (provided by applicant): This proposal describes a 5 year training program for the development of an academic career in Allergy and Immunology. The principal investigator has completed an M.D. at Temple University, residency training in Internal Medicine at Yale University School of Medicine and is currently completing an Allergy and Clinical Immunology fellowship at the same institute. This program will allow the candidate to expand on her previous scientific skills and to become proficient in the fields of asthma pathogenesis and Th2 priming. Dr. Kim Bottomly will mentor the principal investigator's scientific development. Dr. Bottomly is a recognized leader in the field of asthma pathogenesis. Dr. Bottomly is a Professor of Immunobiology and has successfully trained numerous postdoctoral fellows and graduate students. Research will focus on the mechanisms by which Th2 inflammation affects priming of naive CD4 T cells to new environmental antigens. This process occurs by a mechanism distinct from that responsible for Th2 priming in a naive mouse and may occur independently from the innate immune system. Our preliminary data show Th2 cytokines produced during inflammation lead to priming of a new population of Th2 effector cells. The specific aims include: 1) investigation of the role of IL-4 in this model. 2) identification of the target cell upon which IL-4 acts. 3) investigation of the role of IL-13 and identification of the cell upon which IL-13 acts. Asthma is a growing epidemic in developed nations with a huge impact in morbidity and mortality. If we understand the pathogenesis we will be able to apply this to patient care. Our hope is to learn enough to prevent asthma before it develops. This K08 award will greatly assist the candidate's research into asthma pathogenesis and mechanisms of inflammation and provide her with time and resources to develop into a skilled independent investigator.

描述（由申请人提供）：该提案描述了一项为期5年的培训计划，以开发过敏和免疫学领域的学术职业。首席研究人员已在坦普尔大学（Temple University）完成了一项医学博士学位，耶鲁大学医学院内科居住培训，目前正在同一研究所完成过敏和临床免疫学研究金。该计划将使候选人能够扩展她以前的科学技能，并在哮喘发病机理和TH2启动领域熟练。 Kim博士底部将指导主要研究者的科学发展。底部博士是哮喘发病机理领域的公认领导者。 Bottomly博士是免疫生物学教授，并成功地培训了许多博士后研究员和研究生。研究将侧重于Th2炎症影响幼稚CD4 T细胞对新环境抗原的启动的机制。这个过程是通过与幼稚小鼠中Th2启动的机制不同的，并且可能独立于先天免疫系统。我们的初步数据表明，在炎症期间产生的Th2细胞因子导致新的Th2效应细胞启动。具体目的包括：1）研究IL-4在该模型中的作用。 2）识别IL-4作用的靶细胞。 3）研究IL-13的作用和IL-13作用的细胞的鉴定。哮喘是发达国家越来越多的流行病，对发病率和死亡率产生了巨大影响。如果我们了解发病机理，我们将能够将其应用于患者护理。我们的希望是足够学习，以预防哮喘。该K08奖将极大地帮助候选人对哮喘发病机理和炎症机制的研究，并为她提供时间和资源，以发展成熟练的独立研究者。