IImmune Tolerance Network: Airborne Allergens and Allergic Rhintitis

II免疫耐受网络：空气中的过敏原和过敏性鼻炎

• 批准号: 8730013
• 负责人: JEFFREY BLUESTONE
• 金额: $ 485.22万
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8730013
• 关键词: Allergens; Allergic; Allergic rhinitis; Biological Assay; Clinical Research; Conduct Clinical Trials; Disease; Human; Immune Tolerance; Immune response; Immune system; Maintenance; Measures; Monitor; Prevention; airborne allergen; laboratory facility; novel; research clinical testing

The Immune Tolerance Network (ITN) is dedicated to the clinical evaluation of novel tolerance-inducing therapies that will ¿re-educate¿ the immune system to eliminate injurious immune responses. The ITN conducts clinical trials. In addition, to understand the underlying mechanisms of action of the candidate therapies and to monitor tolerance, the ITN has established state of the art core laboratory facilities to conduct integrated mechanistic studies and clinical research, and to develop and evaluate markers and assays to measure induction, maintenance, and loss of tolerance in humans. This project studies disease associated with airborne allergens and allergic rhinitis

免疫耐受网络(ITN)致力于对新的耐受诱导疗法进行临床评估，这些疗法将对免疫系统进行再教育，以消除损伤性免疫反应。ITN进行临床试验。此外，为了了解候选疗法的潜在作用机制并监测耐受性，ITN建立了最先进的核心实验室设施，以进行综合机制研究和临床研究，并开发和评估用于测量人类耐受性诱导、维持和丧失的标志物和分析方法。该项目研究与空气传播的过敏原和过敏性鼻炎有关的疾病。