Regulation of Invasion and Metastasis by HIF-1 Oral Squamous Cell Carcinoma

HIF-1对口腔鳞状细胞癌侵袭和转移的调控

基本信息

  • 批准号:
    7480306
  • 负责人:
  • 金额:
    $ 12.62万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-09-22 至 2011-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Project Summary: Resistance to treatment has been a vexing challenge for oral squamous cell carcinoma (OSCC). Within the tumor microenvironment, OSCC cells rapidly expend oxygen and nutrients supplied by the local vasculature. Although hypoxia may inhibit new cell division or increase cell death, those cells most capable of adapting to hypoxia and hypoglycemia may have a selective advantage leading to increased malignant behavior. Indeed, studies have demonstrated a relationship between tumor hypoxia and increased resistance to radiation therapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that plays an essential role in regulating oxygen homeostasis. Expression and activity of the HIF-1 a subunit is influenced by cellular oxygen concentration, as well as numerous growth factors and signaling pathways. Over 70 HIF-1 target genes have been identified that are crucial for angiogenesis, glycolysis and other adaptive mechanisms. Increased HIF-1 expression within oropharyngeal tumors is correlated with worse patient prognosis. This research project is focused upon the role of HIF-1 in modulating OSCC invasion and metastasis. In Specific Aim 1, we will elucidate the function of HIF-1 in OSCC invasion and metastasis. We will characterize the contribution of HIF-1 to the regulation of candidate genes that mediate invasion and metastasis in OSCC in Specific Aim 2. Understanding the biochemical and molecular basis for the altered regulation of HIF-1 in OSCC could lead to opportunities for new therapeutic interventions to limit OSCC invasion and metastasis and improve patient survival. The candidate is a head and neck oncologic surgeon with a research background in signal transduction and head and neck cancer. His career goal is to translate advances in the understanding of OSCC metastasis and invasion into novel and effective therapeutic interventions for head and neck cancer patients. His institution is committed to this goal and has provided the necessary space, protected time and resources. He has assembled a team of mentors and consultants who will not only provide extensive scientific guidance, but also foster his development as an independent investigator. Relevance: Morbidity and mortality due to head and neck cancers is often related to tumor spread by local invasion and distant metastasis. Understanding the role of HIF-1 in OSCC invasion and metastasis may identify new targets for the development of diagnostic biomarkers and therapies designed to monitor and prevent tumor spread. These studies will directly benefit patients with head and neck cancer and may provide valuable insight into the regulation of tumor spread in other types of cancer.
描述(由申请人提供):项目概述:对治疗的抵抗一直是口腔鳞状细胞癌(OSCC)的一个令人烦恼的挑战。在肿瘤微环境中,OSCC细胞迅速消耗由局部血管系统提供的氧气和营养物质。虽然缺氧可能抑制新的细胞分裂或增加细胞死亡,但那些最能适应缺氧和低血糖的细胞可能具有选择性优势,导致恶性行为增加。事实上,研究已经证明了肿瘤缺氧与对放射疗法和化学疗法的抗性增加之间的关系。缺氧诱导因子1(HIF-1)是一种异源二聚体转录因子,在调节氧稳态中起重要作用。HIF-1 α亚基的表达和活性受细胞氧浓度以及许多生长因子和信号传导途径的影响。已经鉴定了70多个HIF-1靶基因,它们对血管生成、糖酵解和其他适应机制至关重要。口咽部肿瘤中HIF-1表达增加与患者预后不良相关。本研究旨在探讨HIF-1在口腔鳞癌侵袭和转移中的作用。在具体目标1中,我们将阐明HIF-1在口腔鳞癌侵袭和转移中的作用。我们将在特定目标2中描述HIF-1对介导OSCC侵袭和转移的候选基因的调节作用。了解OSCC中HIF-1调节改变的生物化学和分子基础可能会导致新的治疗干预措施,以限制OSCC侵袭和转移并提高患者生存率。 候选人是头颈部肿瘤外科医生,具有信号转导和头颈部癌症的研究背景。他的职业目标是将OSCC转移和侵袭的理解进展转化为头颈部癌症患者的新型有效治疗干预措施。他的机构致力于实现这一目标,并提供了必要的空间、受保护的时间和资源。他组建了一个导师和顾问团队,他们不仅提供广泛的科学指导,还将促进他作为独立研究者的发展。 相关性:头颈部癌症的发病率和死亡率通常与肿瘤局部浸润和远处转移有关。了解HIF-1在OSCC侵袭和转移中的作用可能会为开发旨在监测和预防肿瘤扩散的诊断生物标志物和治疗方法确定新的靶点。这些研究将使头颈癌患者直接受益,并可能为其他类型癌症中肿瘤扩散的调节提供有价值的见解。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

STEPHEN Y LAI其他文献

STEPHEN Y LAI的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('STEPHEN Y LAI', 18)}}的其他基金

Development of miR-27a* for the Treatment of Head and Neck Squamous Cell Carcinoma
开发 miR-27a* 用于治疗头颈鳞状细胞癌
  • 批准号:
    10752726
  • 财政年份:
    2023
  • 资助金额:
    $ 12.62万
  • 项目类别:
Quantification of cisplatin sensitivity and resistance using metabolic imaging and circulating tumor cell (CTC) biomarkers
使用代谢成像和循环肿瘤细胞 (CTC) 生物标志物量化顺铂敏感性和耐药性
  • 批准号:
    10518179
  • 财政年份:
    2022
  • 资助金额:
    $ 12.62万
  • 项目类别:
Quantification of cisplatin sensitivity and resistance using metabolic imaging and circulating tumor cell (CTC) biomarkers
使用代谢成像和循环肿瘤细胞 (CTC) 生物标志物量化顺铂敏感性和耐药性
  • 批准号:
    10707179
  • 财政年份:
    2022
  • 资助金额:
    $ 12.62万
  • 项目类别:
Radiosensitization of thyroid cancer by cancer cell specific reduction of gold ions
癌细胞特异性还原金离子对甲状腺癌的放射增敏作用
  • 批准号:
    10569671
  • 财政年份:
    2022
  • 资助金额:
    $ 12.62万
  • 项目类别:
Radiosensitization of thyroid cancer by cancer cell specific reduction of gold ions
癌细胞特异性还原金离子对甲状腺癌的放射增敏作用
  • 批准号:
    10372483
  • 财政年份:
    2022
  • 资助金额:
    $ 12.62万
  • 项目类别:
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular Osteoradionecrosis
使用动态对比增强磁共振成像 (DCE-MRI) 建立下颌放射性骨坏死的客观临床结果测量
  • 批准号:
    9894640
  • 财政年份:
    2016
  • 资助金额:
    $ 12.62万
  • 项目类别:
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular Osteoradionecrosis
使用动态对比增强磁共振成像 (DCE-MRI) 建立下颌放射性骨坏死的客观临床结果测量
  • 批准号:
    9247170
  • 财政年份:
    2016
  • 资助金额:
    $ 12.62万
  • 项目类别:
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular Osteoradionecrosis
使用动态对比增强磁共振成像 (DCE-MRI) 建立下颌放射性骨坏死的客观临床结果测量
  • 批准号:
    10086515
  • 财政年份:
    2016
  • 资助金额:
    $ 12.62万
  • 项目类别:
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular Osteoradionecrosis
使用动态对比增强磁共振成像 (DCE-MRI) 建立下颌放射性骨坏死的客观临床结果测量
  • 批准号:
    9135823
  • 财政年份:
    2015
  • 资助金额:
    $ 12.62万
  • 项目类别:
Optimizing Radiosensitization in Anaplastic Thyroid Cancer with Metabolic Imaging
通过代谢成像优化甲状腺未分化癌的放射增敏
  • 批准号:
    8879068
  • 财政年份:
    2014
  • 资助金额:
    $ 12.62万
  • 项目类别:

相似国自然基金

greenwashing behavior in China:Basedon an integrated view of reconfiguration of environmental authority and decoupling logic
  • 批准号:
  • 批准年份:
    2024
  • 资助金额:
    万元
  • 项目类别:
    外国学者研究基金项目

相似海外基金

Collaborative Research: Biochemical Basis of Cellular Circadian Behavior
合作研究:细胞昼夜节律行为的生化基础
  • 批准号:
    1854392
  • 财政年份:
    2018
  • 资助金额:
    $ 12.62万
  • 项目类别:
    Standard Grant
Elucidating the mechanical and biochemical signals that regulate the cooperative behavior of collectively migrating cells
阐明调节集体迁移细胞合作行为的机械和生化信号
  • 批准号:
    18K14700
  • 财政年份:
    2018
  • 资助金额:
    $ 12.62万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Collaborative Research: Biochemical Basis of Cellular Circadian Behavior
合作研究:细胞昼夜节律行为的生化基础
  • 批准号:
    1656647
  • 财政年份:
    2017
  • 资助金额:
    $ 12.62万
  • 项目类别:
    Standard Grant
Biochemical and Molecular Basis of Circadian Behavior
昼夜节律行为的生化和分子基础
  • 批准号:
    0920417
  • 财政年份:
    2009
  • 资助金额:
    $ 12.62万
  • 项目类别:
    Standard Grant
A Multi-Scale Approach to Understanding the Mechanical and Biochemical Behavior of Tissue Engineered Blood Vessels
了解组织工程血管的机械和生化行为的多尺度方法
  • 批准号:
    0700507
  • 财政年份:
    2007
  • 资助金额:
    $ 12.62万
  • 项目类别:
    Standard Grant
CompBio: Simulation of self-emerging properties of coupled biochemical and cellular networks in social behavior of Myxobacteria
CompBio:模拟粘细菌社会行为中生化和细胞网络耦合的自生特性
  • 批准号:
    0622940
  • 财政年份:
    2006
  • 资助金额:
    $ 12.62万
  • 项目类别:
    Standard Grant
Biochemical and cookery behavior of arsenic in seaweeds, Hijiki (Sargassum fusiforme) and Akamoku (Sargassum horneri)
海藻、羊栖菜 (Sargassum fusiforme) 和赤木 (Sargassum horneri) 中砷的生化和烹饪行为
  • 批准号:
    18500609
  • 财政年份:
    2006
  • 资助金额:
    $ 12.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
BIOCHEMICAL & BEHAVIOR PROPERTIES OF PRIMARY CILIA: KIDNEY EPITHELIA
生化
  • 批准号:
    6280706
  • 财政年份:
    1998
  • 资助金额:
    $ 12.62万
  • 项目类别:
BIOCHEMICAL ASPECTS OF SUICIDAL BEHAVIOR
自杀行为的生化方面
  • 批准号:
    6117610
  • 财政年份:
    1998
  • 资助金额:
    $ 12.62万
  • 项目类别:
BIOCHEMICAL ASPECTS OF SUICIDAL BEHAVIOR
自杀行为的生化方面
  • 批准号:
    6248823
  • 财政年份:
    1997
  • 资助金额:
    $ 12.62万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了