权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Additional Modules for PAMELA to Enhance Research Efficiency (AMPERE)

PAMELA 提高研究效率的附加模块 (AMPERE)

基本信息

批准号：
EP/G013071/1
负责人：
Nick Tyler
金额：
$ 268.39万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FG013071%2F1
关键词：
Additional Modules PAMELA Enhance Research

项目摘要

AMPERE adds 15 square (i.e. configurable in a single plane) and 11 triangle (configurable in two planes) additional active modules to the PAMELA facility. These are exactly the same as the original motorised modules and have two major benefits: (1) they reduce the time taken for major adjustments and reconficurations from several hours to a few minutes resulting in an increase in availability for research and (2) they allow more comprehensive experimental setups to be incorporated in a single layout. The additional modules require updates to the existing control software, new cables and power/control distribution units in order to ensure that the whole platform can be controlled using the same system and interface as used for the original modules. Four of the square modules (configurable in a single plane) will be fitted with 4 force plates each so that ground resistance forces can be incorporated in the facility. PAMELA is a very complex interdisciplinary facility and the AMPERE enhancements increase the desirability of the facility to other researchers. First, the importance of increasing the availability of PAMELA for researchers in all fields of interest has already been demonstrated in gene therapy by the Institute of Ophthalmology (IoO), where the controlled conditions and monitoring capability of PAMELA have meant that research results have been reached much more quickly and at a much deeper level than would have been possible without a controlled pedestrian environment - PAMELA has allowed before and after testing in an objective, quantifiable and repeatable way whereas the previous methods would have involved just eye tests and subjective interviews to reveal the effects of the intervention. In addition the timescale (pre-Intervention testing in October 2006, Intervention Therapy in spring 2007, post-Intervention testing in February 2008, publication of results in the New England Journal of Medicine in early 2008) shows a clear reduction of time from laboratrory to publication and, more importantly, the potential for faster delievery of the outcomes of basic research to those people who will ultimately benefit - in this case, people with low vision.Secondly, the new modules enable PAMELA to incorporate more complex layouts, thus reducing the need to split experiments to accommodate different features. This makes it much easier for the participants as they need to make fewer visits to the facility and for the researchers because their experiments can be carried out much more quickly. This helps to increase the availability of the facility for all researchers as well as increasing the sophistication of the layouts.Thirdly, the introduction of modules with force plates means that for the first time it will be possible to measure ground resistance forces in complex environments such as longitudinal and lateral slopes and steps so that issues such as the biomechanics of wheelchair propulsion (especially by assistants), balance of older people, understanding of agility and so on can be included in research into pedestrian interactions with the environment.The demand for access to PAMELA is such that it is becoming difficult to fit all requests into a suitable timescale. AMPERE will make a significant difference to the available capacity by increasing it by more than 50% and thus ensure that lack of availability does not hold up the major research advances that can be supported by the facility as demonstrated by the IoO work.AMPERE also includes an AccessGrid node facility. This will enable researchers to communicate with the facility from all over the world when designing and running experiments and will make dissemination from the facility much easier and more comprehensive.

AMPERE为PAMELA设施增加了15个正方形（即可在单个平面中配置）和11个三角形（可在两个平面中配置）额外的有源模块。这些与原始的电动模块完全相同，并且具有两个主要优点：（1）它们将主要调整和重新配置所需的时间从几个小时减少到几分钟，从而增加了研究的可用性;（2）它们允许将更全面的实验设置纳入单一布局中。增加的模块需要更新现有的控制软件、新的电缆和电源/控制分配单元，以确保整个平台可以使用与原始模块相同的系统和接口进行控制。四个方形模块（可配置在单个平面中）将分别配备4个测力板，以便将地面阻力纳入设施中。PAMELA是一个非常复杂的跨学科设施，AMPERE增强功能增加了该设施对其他研究人员的吸引力。首先，眼科研究所（IoO）已经在基因治疗中证明了增加PAMELA对所有感兴趣领域的研究人员的可用性的重要性，PAMELA的受控条件和监测能力意味着研究成果的获得比没有受控行人环境的情况下更快，更深层次-PAMELA允许以客观、可量化和可重复的方式进行前后测试，而以前的方法只涉及视力测试和主观访谈，以揭示干预的效果。此外，时间表（2006年10月的干预前测试，2007年春季的干预治疗，2008年2月的干预后测试，2008年初在新英格兰医学杂志上发表结果）显示从实验室到发表的时间明显减少，更重要的是，更快地将基础研究成果交付给最终受益者的潜力-在这种情况下，低视力的人。其次，新模块使PAMELA能够整合更复杂的布局，因此减少了分开实验以适应不同特征的需要。这使得参与者更容易，因为他们需要更少的访问设施和研究人员，因为他们的实验可以更快地进行。这有助于提高所有研究人员的设施可用性，并增加布局的复杂性。第三，引入带有测力板的模块意味着，第一次有可能在复杂的环境中测量地面阻力，如纵向和横向斜坡和台阶，以便解决轮椅推进的生物力学等问题行人与环境互动的研究可以包括老年人的平衡感、对灵活性的理解等。对PAMELA的访问需求如此之大，以至于很难将所有请求都纳入适当的时间表。AMPERE将使可用容量增加50%以上，从而确保缺乏可用性不会阻碍该设施支持的主要研究进展，正如IoO工作所证明的那样。AMPERE还包括一个可扩展网格节点设施。这将使研究人员在设计和进行实验时能够与世界各地的设施进行交流，并使设施的传播更加容易和全面。