Systems Biology Platform to Study the Influence of Nutrient Compounds on Cancer D

研究营养化合物对癌症 D 影响的系统生物学平台

• 批准号: 7538045
• 负责人: Yuri V. Nikolsky
• 金额: $ 14.05万
• 依托单位: GENEGO, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7538045
• 关键词: Academia; Address; Age of Onset; Biological; Biological Markers; Blood; Cancer Patient; Cancer and Nutrition; Categories; Clinical Data; Collaborations; Collection; Complex Mixtures; Computer software; Computers; Computing Methodologies; Data; Data Analyses; Data Set; Data Sources; Databases; Descriptor; Development; Diagnostic Neoplasm Staging; Diet; Dietary Component; Dietary Intervention; Dimensions; Disease; Disease Progression; Disease model; Drug Receptors; Foundations; Gene Expression; Gene Proteins; Generations; Genes; Genetic Polymorphism; Genetic Transcription; Genome; Health; Hereditary Disease; Human; Imagery; Industry; Java; Knowledge; Leukocytes; Link; Malignant Neoplasms; Marketing; Metabolic; Metabolic Pathway; Molecular; Monitor; Nutrient; Onset of illness; Organ; Outcome; Pathway interactions; Pharmacologic Substance; Phase; Phenotype; Population; Prevention; Prostate-Specific Antigen; Proteins; Proteomics; Public Health; Published Database; Publishing; RNA; Research; Research Personnel; Resources; Risk Factors; Running; Sampling; Science; Signal Transduction; Software Tools; Statistically Significant; System; Systems Analysis; Systems Biology; Technology; Tissues; Today; Transcript; Variant; Work; base; cancer prevention; design; disorder prevention; gene interaction; genetic association; interest; knowledge base; metabolomics; novel; nutrition; prevent; programs; protein protein interaction; research study; tool; transcriptomics; translational medicine

DESCRIPTION (provided by applicant): Early dietary intervention for preventing disease onset or progression requires an understanding of the molecular mechanisms of nutrient-gene interactions contributing to disease. To date, no database or set of analysis tools exists that sufficiently addresses these needs. We propose to develop a database and analysis platform specifically designed for investigating the influence of nutrients on the development and progression of human cancers, comprising i) a comprehensive database of nutrient-protein, nutrient-gene (and polymorphism) interactions, and indirect associations between nutrient compounds and cancer phenotypes such as age of onset, stage of cancer, and association with cancer biomarkers; ii) a comprehensive collection of nutrigenomics datasets (gene-expression, proteomics, metabolomics) and human white blood cell (lymphochip) gene expression experiments; iii) a set of software tools that will enable the analysis of systems biology datasets (including the ability to address different data types together) to construct nutrient-centered metabolic and signaling networks, pathways, and disease models, and to identify potential strategies and targets for nutritional intervention to reduce risk factors and augment treatment. The product will be unique in the marketplace and of great interest to academic researchers, foundations and pharmaceutical companies performing research into the association between diet and disease development. PUBLIC HEALTH RELEVANCE: This proposal aims to develop a knowledge-base and suite of data analysis tools specifically designed to facilitate the design and interpretation of nutrigenomic and nutrigenetic experiments investigating the link between dietary components and human cancer development.

描述（由申请人提供）：预防疾病发作或进展的早期饮食干预需要了解导致疾病的营养素-基因相互作用的分子机制。迄今为止，还没有一个数据库或一套分析工具能够充分满足这些需求。我们建议开发一个专门用于研究营养素对人类癌症发展和进展的影响的数据库和分析平台，包括i）营养素-蛋白质、营养素-基因、营养素-蛋白质和营养素-基因的综合数据库，（和多态性）相互作用，以及营养化合物和癌症表型之间的间接关联，例如发病年龄、癌症阶段，以及与癌症生物标志物的关联; ii）全面收集营养基因组学数据集（基因表达、蛋白质组学、代谢组学）和人白色血细胞（淋巴芯片）基因表达实验; iii）一套软件工具，用于分析系统生物学数据集（包括一起处理不同数据类型的能力）来构建以营养为中心的代谢和信号传导网络、途径和疾病模型，并确定营养干预的潜在战略和目标，以减少风险因素和加强治疗。该产品在市场上将是独一无二的，并对研究饮食与疾病发展之间关系的学术研究人员、基金会和制药公司产生极大的兴趣。公共卫生关系：该提案旨在开发一个知识库和一套专门设计的数据分析工具，以促进营养基因组学和营养遗传学实验的设计和解释，这些实验调查了饮食成分与人类癌症发展之间的联系。