Systems Biology Platform to Study the Influence of Nutrient Compounds on Cancer D

描述（由申请人提供）：预防疾病发生或进展的早期饮食干预需要了解导致疾病的营养-基因相互作用的分子机制。到目前为止，还没有数据库或一组分析工具能够充分满足这些需求。我们建议开发一个专门用于研究营养素对人类癌症发展和进展的影响的数据库和分析平台，包括1)一个全面的营养-蛋白质、营养-基因（和多态性）相互作用的数据库，以及营养化合物与癌症表型（如发病年龄、癌症分期和与癌症生物标志物的关联）之间的间接关联；Ii)营养基因组学数据集（基因表达、蛋白质组学、代谢组学）和人类白细胞（淋巴芯片）基因表达实验的综合收集；Iii)一套软件工具，能够分析系统生物学数据集（包括一起处理不同数据类型的能力），以构建以营养为中心的代谢和信号网络、途径和疾病模型，并确定营养干预的潜在策略和目标，以减少风险因素和增加治疗。该产品将在市场上独一无二，并引起学术研究人员、基金会和制药公司的极大兴趣，这些研究人员正在研究饮食与疾病发展之间的关系。公共卫生相关性：本提案旨在开发一个知识库和一套专门设计的数据分析工具，以促进营养基因组学和营养遗传学实验的设计和解释，研究饮食成分与人类癌症发展之间的联系。

DESCRIPTION (provided by applicant): Early dietary intervention for preventing disease onset or progression requires an understanding of the molecular mechanisms of nutrient-gene interactions contributing to disease. To date, no database or set of analysis tools exists that sufficiently addresses these needs. We propose to develop a database and analysis platform specifically designed for investigating the influence of nutrients on the development and progression of human cancers, comprising i) a comprehensive database of nutrient-protein, nutrient-gene (and polymorphism) interactions, and indirect associations between nutrient compounds and cancer phenotypes such as age of onset, stage of cancer, and association with cancer biomarkers; ii) a comprehensive collection of nutrigenomics datasets (gene-expression, proteomics, metabolomics) and human white blood cell (lymphochip) gene expression experiments; iii) a set of software tools that will enable the analysis of systems biology datasets (including the ability to address different data types together) to construct nutrient-centered metabolic and signaling networks, pathways, and disease models, and to identify potential strategies and targets for nutritional intervention to reduce risk factors and augment treatment. The product will be unique in the marketplace and of great interest to academic researchers, foundations and pharmaceutical companies performing research into the association between diet and disease development. PUBLIC HEALTH RELEVANCE: This proposal aims to develop a knowledge-base and suite of data analysis tools specifically designed to facilitate the design and interpretation of nutrigenomic and nutrigenetic experiments investigating the link between dietary components and human cancer development.