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Real-Time Image and Dose Guided Radiation Therapy System

实时图像和剂量引导放射治疗系统

基本信息

批准号：
7480668
负责人：
PIRAN SIOSHANSI
金额：
$ 15万
依托单位：
ADVANCED RADIATION THERAPY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2009-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Real-Time Image and Dose Guided Radiation Therapy System Development and integration of a real-time image- and dose-guided radiation therapy system is long overdue. Advanced Radiation Therapy has identified an opportunity and designed a single system that uses a common platform for imaging the target tissue in real-time, immobilizing the tissue, delivering radiotherapy, and registering the therapeutic dose. The system is designed primarily for radiotherapy of breast cancer following lumpectomy, but has the potential to be used for other indications. The design combines mammographic image guidance for immobilizing breast tissue between two parallel paddles to identify (localize) the target tissue and non- invasive brachytherapy applicators that are subsequently attached to the paddles for delivering the therapeutic dose. Thus, the patent pending system, for the first time, allows one to practice "... you see what you treat and you treat what you see and then you record what was treated." The design combines multiple treatment directions, each orthogonal to the previous treatment and delivers, under real-time image guidance, a stereotactic therapeutic dose to the target tissue without exceeding the dose tolerance of the intervening normal tissue (including skin dose). The quality of the dose from this non-invasive design is superior to other partial breast irradiation techniques: The dose is uniform throughout the target, homogeneous (no hot/cold spots with a dose homogeneity index of 1), is conformal to the designated tissue, and significantly reduces unintended exposure to neighboring organs (heart, lungs and the contralateral breast). The Phase I research program is designed to complement the extensive on- going pre-clinical streamlining of the system and help with confidence building in the approach. The project, when completed, is expected to have established the reliability, reproducibility, safety, and efficacy of the design for widespread clinical use. PUBLIC HEALTH RELEVANCE: The AccuBoost system represents a unique advancement in the development of an integrated breast brachytherapy treatment. This system provides the clinician assurance of both proper targeting and treatment of the lumpectomy cavity margin for patients electing Breast Conserving Therapy (BCT) through the use of a single platform for imaging, treatment and verification. This project addresses all procedural aspects starting from compatibility with the surgical procedure (imaging of surgical clips), through alignment, delivery of a conformal (tissue sparing) treatment as well as confirmation of treatment delivery.

描述（由申请人提供）：实时图像和剂量引导放射治疗系统实时图像和剂量引导放射治疗系统的开发和集成早就该进行了。 Advanced Radiation Therapy 发现了一个机会，并设计了一个单一系统，该系统使用通用平台对目标组织进行实时成像、固定组织、提供放射治疗并记录治疗剂量。该系统主要设计用于乳腺癌肿瘤切除术后的放射治疗，但也有可能用于其他适应症。该设计结合了用于将乳腺组织固定在两个平行桨之间以识别（定位）目标组织的乳房X线照相图像引导和随后连接到桨上以提供治疗剂量的非侵入性近距离放射治疗施用器。因此，正在申请专利的系统第一次允许人们实践“……你看到你所治疗的东西，你治疗你所看到的东西，然后你记录所治疗的东西。”该设计结合了多个治疗方向，每个方向都与之前的治疗正交，并在实时图像引导下向目标组织输送立体定向治疗剂量，而不超过介入正常组织的剂量耐受性（包括皮肤剂量）。这种非侵入性设计的剂量质量优于其他部分乳房照射技术：整个目标的剂量均匀、均匀（无热点/冷点，剂量均匀性指数为 1），与指定组织保形，并显着减少对邻近器官（心脏、肺和对侧乳房）的意外暴露。第一阶段研究计划旨在补充广泛正在进行的系统临床前精简，并帮助建立对该方法的信心。该项目完成后，预计将确定设计的可靠性、可重复性、安全性和有效性，以供广泛的临床使用。公共健康相关性：AccuBoost 系统代表了综合乳腺近距离放射治疗开发的独特进步。该系统通过使用单一成像、治疗和验证平台，为选择保乳治疗 (BCT) 的患者提供正确的肿瘤切除腔边缘定位和治疗保证。该项目解决了所有程序方面的问题，从与手术程序的兼容性（手术夹的成像）开始，到对齐、适形（组织保护）治疗的实施以及治疗实施的确认。