PROSTATE CANCER RADIONUCLIDE SOURCES BY ION IMPLANTATION

描述：近距离放射治疗，或间质放射治疗，是一种成功的 前列腺癌的治疗方法。在近距离放射治疗中， 水稻籽粒大小的Pd-103或碘-125种子数(50-100)为 插入到前列腺中，用于传递局部辐射和 根除癌细胞。前列腺近距离放射治疗的结果数据 从无数的中心，到八年，证明了这一点 技术导致很高的阴性活检率，并且在大多数情况下 病例中，本病无顽固性。目前的提案针对的是 线性间质放射治疗源的研究进展 由离子注入技术生产。放射性核素离子 离子注入直接在薄铂上产生密封源 “微电线”。这些新的近距离放射治疗资源提供以下功能 优点：1.线形几何，具有均匀的可控性 三维剂量分布；2.长度可调的源(可 剪裁成任意长度)；3.极佳的可推性，便于快速释放 针头；4.更薄的外形，便于插入和最小压盖 移位；5.减少源放置的过程时间， 减少与医生和其他人员的接触；6.最低限度地 迁移和迁移；7.大大扩展的放射性核素选择 满足患者的特定剂量和剂量分布要求； 可靠、可重复、自动化制造；9.大大降低了成本。 建议的商业应用：不可用

DESCRIPTION: Brachytherapy, or interstitial radiation, is a successful approach for treatment of prostate cancer. In brachytherapy, a large number (50-100) of rice grain-sized seeds of Pd-103 or Iodine-125 are inserted into the prostate gland for delivering local radiation and eradicating cancerous cells. Outcome data for prostate brachytherapy from numerous centers, out to eight years, demonstrates that this technique results in high negative biopsy rates and, in a large majority of cases, no persistence of the disease. The current proposal addresses the development of linear interstitial radiation therapy sources produced by the ion implantation technology. Radionuclide ion implantation creates a sealed source directly on thin gauge platinum "micro-wires". These new brachytherapy sources offer the following advantages: 1. linear geometry, with uniform activity for controllable 3-dimensional dose distribution; 2. adjustable length source (can be cut to any length); 3. excellent pushability for quick release through the needle; 4. thinner profile for ease of insertion and minimum gland displacement; 5. reduce procedure time for source placement and thus, less exposure to physicians and other personnel; 6. minimum chance of migration and dislodgment; 7. vastly expanded radionuclide selection for patient specific dose and dose distribution requirements; 8. reliable, reproducible, automated manufacturing; 9. much reduced cost. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE