MINIMALLY INVASIVE PROBE FOR IN-VIVO DETECTION OF IRON

用于铁体内检测的微创探针

• 批准号: 2803537
• 负责人: PIRAN SIOSHANSI
• 金额: $ 10万
• 依托单位: RADIOMED CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-18 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2803537
• 关键词: biomedical equipment development; clinical biomedical equipment; iron storage disorder; metabolism disorder diagnosis; thalassemia

Young patients suffering from Cooley's anemia experience a life threatening accumulation of iron, particularly in the heart and liver. Effective removal of deposited iron by chelating drugs requires a timely and accurate assessment of iron level in the patient. There is an urgent need for development of a rapid, inexpensive and safe method to determine the iron concentration in the organ tissues of Cooley's anemia patients. This proposed contract address the development of an innovative probe for in-situ, real-time detection of iron deposits, as well as levels of certain other trace elements. The technology is based upon a x-ray fluorescence system assembled at the tip of a minimally-invasive 3.2 mm diameter probe. The probe can be introduced in place of a biopsy needle, either laparoscopically or through various anatomical passageways. It is designed to make intimate contact with heart, liver, and other organ tissues to take a direct reading of trace element content. The innovation introduced is a significant improvement over existing technology and for the first time, allows the detection of trace elements in body tissues at the patient's bedside.

患有库利贫血的年轻患者体验生活 威胁铁的积累，特别是在心脏和肝脏中。 通过螯合药物有效去除沉积的铁需要及时 并准确评估患者的铁水平。有紧急情况 需要开发一种快速、廉价且安全的方法来确定 库利贫血患者器官组织中的铁浓度。 该拟议合同涉及开发一种创新探针 原位、实时检测铁沉积物以及铁沉积物的水平 某些其他微量元素。该技术基于 X 射线 荧光系统组装在微创 3.2 mm 的尖端 直径探头。探针可以代替活检针引入， 通过腹腔镜或通过各种解剖通道。这是 旨在与心脏、肝脏和其他器官密切接触 组织直接读取微量元素含量。创新 的推出是对现有技术的重大改进 首次允许检测人体组织中的微量元素 病人的床边。