临床核心-猫眼课题宝

临床核心

批准号：

7494082

负责人：

HARVEY Ira PASS

金额：

$10.71万

依托单位：

UNIVERSITY OF HAWAII AT MANOA

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/7494082

关键词：

Adult Air Aliquot Antibiotics Antibodies Appendix Asbestos Back Beds Benign Binding Biological Biological Preservation Biopsy Biopsy Specimen Blast Cell Buffers Carbon Carbon Dioxide Cell Fraction Cell Line Cells Centrifugation Chest Tubes Chloroform Chromosomes, Human, Pair 8 Clinical Clinical Data Collection Condition Congestive Heart Failure Core Biopsy Count Country Culture Media Cultured Cells DNA DNA Sequence Data Date of birth Decontamination Detection Diagnosis Digestion Disease Drug or chemical Tissue Distribution Dry Ice Electron Microscope Electrons Endopeptidase K Engineering Epidemiologic Studies Equipment Ethanol Event Excision Facility Construction Funding Category Fiber Fibers, A Film Freezing Fresh Tissue Gel Gender Generations Genes Genome Genomics Gold Growth Hamsters Hand Hematoxylin and Eosin Staining Method Homidium Bromide Hospitals Hour Housing Human Human Genome Individual Informed Consent Institutes Investigation Laboratories Light Liquid substance Lung Lung nodule Malignant - descriptor Malignant Mesothelial Cell Malignant Neoplasms Malignant mesothelioma Malignant neoplasm of lung Mesothelial Cell Mesothelioma Mesothelium Methodology Microscopic Mineral Fibers Minority Molecular Molecular Weight Morphology Mutate Nature Needles Nitrogen Non-Malignant Normal tissue morphology Nucleic Acid Regulatory Sequences Nucleic Acids Numbers Operating Rooms Operative Surgical Procedures Oxygen PO-1 Paraffin Paraffin Embedding Pathologic Pathology Patients Performance Peritoneum Phenols Plasma Plasmid Cloning Vector Plasmids Play Pleura Pleural Pleural effusion disorder Polymerase Chain Reaction Polyomavirus Population Potassium Hydroxide Procedures Purpose RNA Race Reaction Reading Reagent Recommendation Recording of previous events Recovery Replication Origin Research Research Personnel Resources Risk Role Sampling Sepharose Serum Services Shipping Ships Shoes Side Simian virus 40 Site Slide Source Southern Blotting Specimen Staging Staining method Stains Standards of Weights and Measures Structure of parenchyma of lung Surface Techniques Testing Thoracic Oncology Thoracotomy Time Tissue Banks Tissue Microarray Tissue Sample Tissues Transmission Electron Microscopy Trypsin Tube Tumor Cell Line Tumor Tissue Validation Variant Veterans Hospitals Vial device Viral Virus Water Week Weight Work abstracting ammonium acetate anticancer research aqueous base beta Globin calretinin cancer care cancer cell carcinogenesis cohort day design effusion feeding flasks foot isopentyl alcohol neoplastic cell outreach particle planetary Atmosphere prevent programs research facility response senescence tissue culture tumor tumorigenesis

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英文摘要

The Clinical Core housed at the Karmanos Cancer Institute is intended to be a resource for the program project as a whole and as a valuable source of biological materials necessary for the completion of the individual projects. The Clinical Core will be responsible for the collection, storage, and distribution of mesothelial cells and tissues, and mesothelioma tumors. The functions of the Clinical Core will be to serve as a resource for mesothelioma tumor tissue both snap frozen and paraffin embedded, and as a resource for asbestos-exposed pleura, lung, or peritoneum which is either snap frozen or paraffin embedded. The CORE will also serve as a resource for already established mesothelioma cell lines as well as an ongoing source of cultured human mesothelial cells from patients at the Karmanos Cancer Institute. New mesothelioma cell lines will be started prospectively from mesothleioma patients having resection. The Core will be responsible for the determining the SV40 status on these human mesothelial tissues, mesothelial cells, mesothelioma tumors and cultured mesothelioma cell lines in order to provide the appropriate reagents to the investigators. Tissue arrays for immunohistochemical validation of data will be constructed from paraffin embedded tumors and provided to the individual investigators. The Clinical Core will also coordinate the performance of asbestos lung content analysis from patients with mesothelioma for correlative data in the individual projects. It is estimated that 60-80 new mesothelioma cases per year will be seen at the Karmanos Cancer Institute during the course of the program project, and it is conservatively estimated that 20-30 of these will be accrued as fresh/frozen specimens. Paraffin embedded tumors will be available from all cases. Tumor samples will be used in Projects 1 and 3, and cell lines/cultures will be used in projects 2 and 3. By centralizing these services into a Core, the collection, storage, analysis, and distribution of tissues relevant to mesothelioma carcinogenesis will be better managed and coordinated for the entire Program Project.

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