SPF COLONY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central objective of this project is to breed SPF macaque monkeys (chiefly rhesus monkeys of Indian ancestry) that are specific pathogen free (SPF) and genetically characterized - as defined by the National Center for Research Resources in RFA RR-02-005; specifically to provide subjects to NIH supported investigators for AIDS related research and thus to contribute to national health priorities. This objective is achieved at the YNPRC by utilizing an existing colony of SPF macaque monkeys. Specifically, a colony of SPF rhesus of Indian ancestry is grown via breeding, recruitment of young animals from YNPRC non-SPF breeding colonies and via appropriate testing and separation. The overall aim of the project is to provide all the trained personnel and resources that are necessary to maintain and enlarge SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities established by NIH and NCRR. The YNPRC will work closely with NCRR and the Coordinating Committee they have established in implementing recommendations regarding uniform husbandry procedures, standarization of screening tests and such other matters as the committee may decide. The YNPRC works in coordination with other facilities maintaining NCRR supported SPF colonies and with any investigators identified by NCRR to maximize the potential that national priorities for SPF production will be attained.