PRECLINICAL STUDIES ON NONHUMAN PRIMATE ENDOMETRIAL XENOGRAFTS

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endometriosis is a chronic disease where endometrium-like tissue forms lesions at sites outside the uterus. Our goal is to test potential new therapies for endometriosis. To do this, we developed a novel model in which rhesus macaque endometrium is transplanted into immunodeficient transgenic RAG-2/cgamma KO mice, which are incapable of rejecting xenografts. The endometrial xenografts grow in response to estrogen and undergo cyclic breakdown similar to endometriosis in women. Our plan is to treat the mice with novel therapies including progesterone receptor (PR) A/B-specific ligands, estrogen receptor beta antagonists, etc. Our aim is to assess the safety and efficacy of these therapies prior to developing clinical trials in women.