PRECLINICAL STUDIES ON NONHUMAN PRIMATE ENDOMETRIAL XENOGRAFTS

非人灵长类子宫内膜异种移植物的临床前研究

• 批准号: 7561979
• 负责人: OV D SLAYDEN
• 金额: $ 7.59万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561979
• 关键词: Chronic Disease; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Endometrial; Endometrium; Estrogen Receptor beta; Estrogens; Funding; Goals; Grant; Institution; Lesion; Ligands; Macaca mulatta; Modeling; Mus; Prior Therapy; Research; Research Personnel; Resources; Safety; Site; Source; Testing; Tissues; Transgenic Organisms; Transplantation; Treatment Efficacy; United States National Institutes of Health; Uterus; Woman; Xenograft procedure; endometriosis; nonhuman primate; novel; preclinical study; progesterone receptor A; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endometriosis is a chronic disease where endometrium-like tissue forms lesions at sites outside the uterus. Our goal is to test potential new therapies for endometriosis. To do this, we developed a novel model in which rhesus macaque endometrium is transplanted into immunodeficient transgenic RAG-2/cgamma KO mice, which are incapable of rejecting xenografts. The endometrial xenografts grow in response to estrogen and undergo cyclic breakdown similar to endometriosis in women. Our plan is to treat the mice with novel therapies including progesterone receptor (PR) A/B-specific ligands, estrogen receptor beta antagonists, etc. Our aim is to assess the safety and efficacy of these therapies prior to developing clinical trials in women.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 子宫内膜异位症是一种慢性疾病，子宫内膜样组织在子宫以外的部位形成病变。我们的目标是测试治疗子宫内膜异位症的潜在新疗法。为此，我们开发了一种新的模型，将恒河猴子宫内膜移植到免疫缺陷的转基因RAG-2/cGamma KO小鼠中，这些小鼠不能排斥异种移植。异种子宫内膜移植对雌激素的反应而生长，并经历类似于女性子宫内膜异位症的周期性破裂。我们的计划是用新的疗法治疗小鼠，包括孕激素受体(PR)A/B特异性配体、雌激素受体β拮抗剂等。我们的目标是在开发女性临床试验之前评估这些疗法的安全性和有效性。