PRECLINICAL STUDIES ON NONHUMAN PRIMATE ENDOMETRIAL XENOGRAFTS
非人灵长类子宫内膜异种移植物的临床前研究
基本信息
- 批准号:7958461
- 负责人:
- 金额:$ 8.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-04 至 2010-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgonistClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseEndometrialEndometriumEstradiolEstrogen Receptor alphaEstrogen Receptor betaFundingGoalsGrantInstitutionKnockout MiceLesionMacacaMediatingModelingPrimatesResearchResearch PersonnelResourcesSafetySiteSourceTestingTissuesTransgenic OrganismsTransplantationUnited States National Institutes of HealthUterusWomanXenograft procedureendometriosisinhibitor/antagonistnonhuman primatepreclinical studyresponse
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Endometriosis is a condition where endometrium-like tissue forms lesions at sites outside the uterus. Our goal is to test potential therapies for endometriosis. To do this we have developed a model in which we transplant macaque endometrium into immunodeficient transgenic RAG-2/c-gamma null mice, which are incapable of rejecting xenografts. The endometrial xenografts grow in response to estradiol (E2) and undergo cyclic breakdown similar to endometriosis in women. Recent studies indicate estrogen receptor (ER) alpha mediates the proliferative effects of E2 in endometriosis and that ER beta could act as an inhibitor of ER alpha action. In this study our aim was to assess the safety and efficacy of ER beta agonist therapy for endometriosis prior to developing clinical trials in women.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('OV D SLAYDEN', 18)}}的其他基金
Imaging and treatment of endometriosis in nonhuman primates
非人灵长类动物子宫内膜异位症的影像学和治疗
- 批准号:
10700030 - 财政年份:2021
- 资助金额:
$ 8.03万 - 项目类别:
Development of magnetic hyperthermia for the systemic treatment of endometriosis
磁热疗系统治疗子宫内膜异位症的进展
- 批准号:
10490250 - 财政年份:2021
- 资助金额:
$ 8.03万 - 项目类别:
Imaging and treatment of endometriosis in nonhuman primates
非人灵长类动物子宫内膜异位症的影像学和治疗
- 批准号:
10309094 - 财政年份:2021
- 资助金额:
$ 8.03万 - 项目类别:
Imaging and treatment of endometriosis in nonhuman primates
非人灵长类动物子宫内膜异位症的影像学和治疗
- 批准号:
10474484 - 财政年份:2021
- 资助金额:
$ 8.03万 - 项目类别:
A nanoparticle-based approach for surgical imaging and intraoperative treatment of endometriosis
基于纳米颗粒的子宫内膜异位症手术成像和术中治疗方法
- 批准号:
10112277 - 财政年份:2020
- 资助金额:
$ 8.03万 - 项目类别:
A nanoparticle-based approach for surgical imaging and intraoperative treatment of endometriosis
基于纳米颗粒的子宫内膜异位症手术成像和术中治疗方法
- 批准号:
9893322 - 财政年份:2020
- 资助金额:
$ 8.03万 - 项目类别:
A macaque model for endometriosis induced pelvic pain and infertility
子宫内膜异位症引起的盆腔疼痛和不孕症的猕猴模型
- 批准号:
8512128 - 财政年份:2013
- 资助金额:
$ 8.03万 - 项目类别:
A macaque model for endometriosis induced pelvic pain and infertility
子宫内膜异位症引起的盆腔疼痛和不孕症的猕猴模型
- 批准号:
8666680 - 财政年份:2013
- 资助金额:
$ 8.03万 - 项目类别:
ANALYSIS OF RNA FROM ECTOPIC ENDOMETRIUM IN RHESUS MACAQUES
恒河猴异位子宫内膜 RNA 分析
- 批准号:
8357805 - 财政年份:2011
- 资助金额:
$ 8.03万 - 项目类别:
PRECLINICAL STUDIES ON HUMAN FIBROIDS IN IMMUNODEFICIENT MICE
免疫缺陷小鼠人体肌瘤的临床前研究
- 批准号:
8357768 - 财政年份:2011
- 资助金额:
$ 8.03万 - 项目类别:
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