Developmental Research Program

发展研究计划

基本信息

  • 批准号:
    7727540
  • 负责人:
  • 金额:
    $ 7.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-07-01 至 2014-06-30
  • 项目状态:
    已结题

项目摘要

As described in the Leadership and Administration Core, an interdisciplinary group of senior leaders is available to interact with each other on a variety of substantive committees - two of which serve to evaluate developmental research studies and guide decision making on the use of stored specimens or the collecfion of prospective specimens needed to conduct these studies. In this section of the SPORE proposal we describe the allocafion of SPORE resources to DRP projects. There are four kinds of SPORE resources: funding to support the research costs of developmental studies, access to stored specimens for use in developmental studies, access to a pafient population with the potenfial to collect prospective specimens to support developmental studies, and data describing prior characterizafion of banked annotated specimens. In recognifion of rapidly changing technology and new and novel applications of such technology for research, approximately $176,000 in total costs will be available per year in the Developmental Research Program (DRP) budget. Matching insfitufional funds from Fred Hutchinson Cancer Research Center (FHCRC) will be available at the discrefion ofthe PI for outstanding ovarian SPORE developmental research projects that address SPORE priorifies in risk assessment and early detecfion, immunotherapy, molecular signatures, and development of novel treatments of ovarian cancer (see FHCRC letter of institufional commitment). Through early detecfion we hope to improve outcomes significanfiy, because 1) currently available treatments are more effective in disease confined to the ovary, and 2) we will develop novel, relatively non-toxic treatments that will be particularly effective in early-stage disease. The tools of molecular biology, immunology and immunotherapy are emphasized in the translational research program. The POCRC is a communitybased, mulfidisciplinary, translafional research program that involves clinicians, laboratory scienfists and public health scientists from several research and medical insfitufions in the region. The broad based approach takes full advantage ofthe scientific expertise available locally and allows the pooling of clinical resources, thus facilitafing population-based studies despite the low incidence of ovarian cancer. Applications will be solicited annually for use of these funds, and each applicafion will be reviewed for its scientific merit and its resource needs including access to specimens. This secfion of the SPORE application oufiines the POCRC's system for evaluafion of developmental research study applicafions and progress. It also includes a summary report on previously funded or on-going projects, as well as several examples of projects that might be inifiated next year if funding is available. Dr. Martin Mcintosh, program leader, will oversee this program and the Executive Committee will evaluate the progress ofthe funded developmental research studies. This program has, and will continue to be, flexible in nature and funding priorities will change according to scientific needs ofthe overall program. Excifing laboratory science with translafional potenfial is a high priority. DRP applicafions should be designed to develop within a couple years into full-scale translafional research projects suitable for a SPORE or ROI applicafion. As collaboration between a laboratory, clinical and/or public health scienfist greafiy facilitates translational research, DRP projects are usually co-directed by an interdisciplinary team of two invesfigators. Inclusion of a POCRC/SPORE investigator as a co-director facilitates integrafion with SPORE themes and appropriate use of the SPORE core resources. Since 1999, the POCRC DRP has funded 29 developmental research proposals with approximately $1.5 million in total funding support. A total of 66 applications have been reviewed, for a funding rate of 44%. We vvill continue to use the current peer-review process to select new projects to be supported by SPORE resources, as it has been very successful.. SPORE funds have been awarded to highly meritorious applicants proposing studies that complement on-going POCRC projects and meet translafional research criteria each year. Six of the DRP awards have led to new projects (Projects 4 and 5) or new roles in the next funding period for an invesfigator (Tewari, Swisher, Salazar, and Knudsen). DRP funds have been used to grow new scientific projects and project leaders in the current SPORE award and in this applicafion, as can be seen in Table 1. The process that is in place will be used during the next funding period, as described below.
正如《领导和管理核心》中所述,一个由高级领导人组成的跨学科小组可以在各种实质性委员会上相互交流,其中两个委员会负责评估发展研究,并指导有关使用储存标本或收集进行这些研究所需的前瞻性标本的决策。在《孢子》提案的这一部分中,我们描述了《孢子》资源在DRP项目中的分配。孢子资源有四种类型:资助发展研究的研究费用,获取用于发展研究的储存标本,获取有可能收集未来标本以支持发展研究的患者群体,以及描述储存的注释标本的先前特征的数据。认识到迅速变化的技术以及这些技术用于研究的新颖应用,

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MARTIN MCINTOSH其他文献

MARTIN MCINTOSH的其他文献

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{{ truncateString('MARTIN MCINTOSH', 18)}}的其他基金

Profiling cancer neoantigen repertoires and validating immunotherapy targets
分析癌症新抗原库并验证免疫治疗靶点
  • 批准号:
    8865578
  • 财政年份:
    2013
  • 资助金额:
    $ 7.23万
  • 项目类别:
Profiling cancer neoantigen repertoires and validating immunotherapy targets
分析癌症新抗原库并验证免疫治疗靶点
  • 批准号:
    8656668
  • 财政年份:
    2013
  • 资助金额:
    $ 7.23万
  • 项目类别:
Profiling cancer neoantigen repertoires and validating immunotherapy targets
分析癌症新抗原库并验证免疫治疗靶点
  • 批准号:
    9070627
  • 财政年份:
    2013
  • 资助金额:
    $ 7.23万
  • 项目类别:
Profiling cancer neoantigen repertoires and validating immunotherapy targets
分析癌症新抗原库并验证免疫治疗靶点
  • 批准号:
    8495657
  • 财政年份:
    2013
  • 资助金额:
    $ 7.23万
  • 项目类别:
Biostatistics and Informatics Core
生物统计学和信息学核心
  • 批准号:
    7727539
  • 财政年份:
    2009
  • 资助金额:
    $ 7.23万
  • 项目类别:
BIOMEDICAL (BASIC)
生物医学(基础)
  • 批准号:
    7938473
  • 财政年份:
    2009
  • 资助金额:
    $ 7.23万
  • 项目类别:
Affinity-based Seurm Proteomics: Breast/Ovarian Cancer
基于亲和力的 Seurm 蛋白质组学:乳腺癌/卵巢癌
  • 批准号:
    7280310
  • 财政年份:
    2005
  • 资助金额:
    $ 7.23万
  • 项目类别:
Affinity-Based Serum Proteomics: Breast and Ovarian Can*
基于亲和力的血清蛋白质组学:乳腺癌和卵巢癌*
  • 批准号:
    7003892
  • 财政年份:
    2005
  • 资助金额:
    $ 7.23万
  • 项目类别:
Affinity-based Seurm Proteomics: Breast/Ovarian Cancer
基于亲和力的 Seurm 蛋白质组学:乳腺癌/卵巢癌
  • 批准号:
    7668583
  • 财政年份:
    2005
  • 资助金额:
    $ 7.23万
  • 项目类别:
Affinity-based Seurm Proteomics: Breast/Ovarian Cancer
基于亲和力的 Seurm 蛋白质组学:乳腺癌/卵巢癌
  • 批准号:
    7482483
  • 财政年份:
    2005
  • 资助金额:
    $ 7.23万
  • 项目类别:

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