Developmental Research Program

如领导和管理核心所述，一个由高级领导人组成的跨学科小组可在各种实质性委员会中相互交流-其中两个委员会负责评估发展研究，并指导关于使用储存标本或收集进行这些研究所需的预期标本的决策。在SPORE建议书的这一部分，我们描述了如何将SPORE资源分配给DRP项目。有四种类型的孢子资源：资助发展研究的研究费用，获得用于发展研究的储存标本，获得有潜力收集前瞻性标本以支持发展研究的pafient人群，以及描述库存注释标本先前特征的数据。在迅速变化的技术和这种技术的新的和新颖的研究应用方面， 发展研究计划（DRP）预算中每年将提供约176，000美元的总费用。Fred哈钦森癌症研究中心（FHCRC）将在PI会议上提供匹配的适当资金，用于突出的卵巢孢子发育研究项目，这些项目将优先解决孢子在风险评估和早期检测、免疫治疗、分子特征和卵巢癌新治疗方法开发方面的问题（见FHCRC机构承诺函）。 通过早期检测，我们希望显著改善结局，因为1）目前可用的治疗方法对局限于卵巢的疾病更有效，2）我们将开发新的，相对无毒的治疗方法，对早期疾病特别有效。分子生物学，免疫学和免疫治疗的工具在转化研究计划中得到强调。POCRC是一个以社区为基础的、多学科的、跨学科的研究项目，涉及该地区几个研究和医疗机构的临床医生、实验室科学家和公共卫生科学家。这种基础广泛的方法充分利用了当地现有的科学专业知识，并允许汇集临床资源，从而促进了基于人群的研究，尽管卵巢癌的发病率很低。 每年将征集使用这些资金的申请，并将审查每一项申请的科学价值和资源需求，包括获取标本的机会。SPORE应用程序的这一部分概述了POCRC用于评估发展研究应用程序和进展的系统。它还包括一份关于以前资助的或正在进行的项目的简要报告，以及几个项目的例子 如果资金到位的话，明年可能会启动。 博士项目负责人马丁·麦金托什将监督该项目，执行委员会将评估 获资助的发展研究的进展。该计划已经并将继续保持灵活性， 项目的性质和资助重点将根据整个项目的科学需要而变化。兴奋 实验室科学具有很高的优先级。DRP应用程序应设计为 在几年内发展成适合SPORE或ROI的全面的商业研究项目 应用由于实验室、临床和/或公共卫生科学之间的合作， 在转化研究中，DRP项目通常由两名投资者组成的跨学科团队共同指导。 将一名太平洋区域合作中心/海洋环境保护与海洋研究项目调查员作为共同主任，有助于与海洋环境保护与海洋研究项目的主题相结合， 合理利用核心资源。 自1999年以来，POCRC DRP资助了29项发展研究提案，约1.5美元 亿元的资金支持。共审查了66份申请，供资率为44%。我们 vvill将继续使用当前的同行评审流程来选择将由SPORE支持的新项目 资源，因为它是非常成功的。SPORE基金已被授予非常有价值的申请人 提出补充正在进行的POCRC项目的研究，并满足每个项目的研究标准 年其中六个DRP奖项导致了新的项目（项目4和5）或下一次资助的新角色 一个投资者（Tewari，Swisher，Salazar和Knudsen）的时期。DRP资金已用于发展新的 科学项目和项目领导人在当前的SPORE奖和本申请中，可以看出， 表1.下一个供资期间将采用现行程序，详情如下。

As described in the Leadership and Administration Core, an interdisciplinary group of senior leaders is available to interact with each other on a variety of substantive committees - two of which serve to evaluate developmental research studies and guide decision making on the use of stored specimens or the collecfion of prospective specimens needed to conduct these studies. In this section of the SPORE proposal we describe the allocafion of SPORE resources to DRP projects. There are four kinds of SPORE resources: funding to support the research costs of developmental studies, access to stored specimens for use in developmental studies, access to a pafient population with the potenfial to collect prospective specimens to support developmental studies, and data describing prior characterizafion of banked annotated specimens. In recognifion of rapidly changing technology and new and novel applications of such technology for research, approximately $176,000 in total costs will be available per year in the Developmental Research Program (DRP) budget. Matching insfitufional funds from Fred Hutchinson Cancer Research Center (FHCRC) will be available at the discrefion ofthe PI for outstanding ovarian SPORE developmental research projects that address SPORE priorifies in risk assessment and early detecfion, immunotherapy, molecular signatures, and development of novel treatments of ovarian cancer (see FHCRC letter of institufional commitment). Through early detecfion we hope to improve outcomes significanfiy, because 1) currently available treatments are more effective in disease confined to the ovary, and 2) we will develop novel, relatively non-toxic treatments that will be particularly effective in early-stage disease. The tools of molecular biology, immunology and immunotherapy are emphasized in the translational research program. The POCRC is a communitybased, mulfidisciplinary, translafional research program that involves clinicians, laboratory scienfists and public health scientists from several research and medical insfitufions in the region. The broad based approach takes full advantage ofthe scientific expertise available locally and allows the pooling of clinical resources, thus facilitafing population-based studies despite the low incidence of ovarian cancer. Applications will be solicited annually for use of these funds, and each applicafion will be reviewed for its scientific merit and its resource needs including access to specimens. This secfion of the SPORE application oufiines the POCRC's system for evaluafion of developmental research study applicafions and progress. It also includes a summary report on previously funded or on-going projects, as well as several examples of projects that might be inifiated next year if funding is available. Dr. Martin Mcintosh, program leader, will oversee this program and the Executive Committee will evaluate the progress ofthe funded developmental research studies. This program has, and will continue to be, flexible in nature and funding priorities will change according to scientific needs ofthe overall program. Excifing laboratory science with translafional potenfial is a high priority. DRP applicafions should be designed to develop within a couple years into full-scale translafional research projects suitable for a SPORE or ROI applicafion. As collaboration between a laboratory, clinical and/or public health scienfist greafiy facilitates translational research, DRP projects are usually co-directed by an interdisciplinary team of two invesfigators. Inclusion of a POCRC/SPORE investigator as a co-director facilitates integrafion with SPORE themes and appropriate use of the SPORE core resources. Since 1999, the POCRC DRP has funded 29 developmental research proposals with approximately $1.5 million in total funding support. A total of 66 applications have been reviewed, for a funding rate of 44%. We vvill continue to use the current peer-review process to select new projects to be supported by SPORE resources, as it has been very successful.. SPORE funds have been awarded to highly meritorious applicants proposing studies that complement on-going POCRC projects and meet translafional research criteria each year. Six of the DRP awards have led to new projects (Projects 4 and 5) or new roles in the next funding period for an invesfigator (Tewari, Swisher, Salazar, and Knudsen). DRP funds have been used to grow new scientific projects and project leaders in the current SPORE award and in this applicafion, as can be seen in Table 1. The process that is in place will be used during the next funding period, as described below.