HCV CENTER STUDIES ON INFECTIOUS HCV

HCV 中心关于传染性 HCV 的研究

• 批准号: 7957898
• 负责人: Robert E LANFORD
• 金额: $ 2.74万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957898
• 关键词: Antiviral Agents; Chronic; Chronic Hepatitis C; Cirrhosis; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Goals; Grant; Hepatitis C virus; Individual; Infection; Infectious hepatitides; Institution; Liver diseases; Malignant neoplasm of liver; Molecular; Molecular Cloning; Pan Genus; Population; Primates; Research; Research Personnel; Resources; Ribavirin; Source; Testing; United States National Institutes of Health; Vaccines; Viral; improved; interferon therapy; tissue culture

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 2% of the US population in chronically infected with hepatitis C virus (HCV). Chronic HCV infections result in significant liver disease including cirrhosis and liver cancer in approximately 20%of infected individuals. The current therapy of interferon and ribavirin does not result in viral clearance in the majority of cases. A better understanding of the replication of HCV at a molecular level as well as the factors that determine whether an infection will proceed to chronic infection or viral clearance are essential for the development of improved antiviral strategies. These studies are important for both vaccine and antiviral development. This is subcontract from the SOUTHEASTERN COOPERATIVE HEPATTIS C RESEARCH GROUP (0024). The goal was to test a molecular clone of HCV that replicates in tissue culture for replication in chimpanzees.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 约2%的美国人口慢性感染丙型肝炎病毒（HCV）。 慢性HCV感染导致严重的肝脏疾病，包括肝硬化和肝癌，约20%的感染者。 目前的干扰素和利巴韦林治疗在大多数情况下不能清除病毒。 更好地了解HCV在分子水平上的复制以及决定感染是否会发展为慢性感染或病毒清除的因素对于开发改进的抗病毒策略至关重要。 这些研究对疫苗和抗病毒药物的开发都很重要。 这是东南部丙型肝炎合作研究组（0024）的研究人员。他们的目标是测试一种在组织培养中复制的HCV分子克隆在黑猩猩中的复制能力。