KNEE STIFFNESS, PROPRIOCEPTION AND INSTABILTIY AFFECT KNEE CONTROL IN OA

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 大量的研究已经确定，内侧膝关节OA（MKOA）患者通常具有股四头肌无力，膝关节内收力矩过大和内侧关节过度松弛，所有这些都可能导致膝关节软骨侵蚀。 然而，除了股四头肌加强计划，有一个缺乏的康复策略，已显示出显着改善关节功能。这项工作的长期目标是制定患者特定的康复计划，以帮助改善功能，同时减少MKOA的进展。 拟议工作的目标是了解股四头肌力量、膝关节僵硬、本体感觉和不稳定性如何促进疾病进展，以及内侧肌肉共同收缩是否是一种减少或加剧OA进展的策略。 研究中获得的知识将使我们能够了解哪些可改变的特征（膝关节僵硬和不稳定，以及内侧肌肉共同收缩）将改善膝关节功能，而不会进一步造成关节损伤，并开发筛选工具，以正确识别将从康复计划中受益的患者。 布坎南博士将担任科学导师，斯奈德-麦克勒博士将担任职业导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A myriad of studies have identified that people with medial knee OA (MKOA) typically have weak quadriceps femoris muscles, excessive knee adduction moments and excessive mediolateral joint laxity all of which can contribute to erosion of cartilage in the knee. However, other than quadriceps strengthening programs, there is a dearth of rehabilitation strategies that have shown marked improvement of joint function. The long term goal of this work is to develop patient specific rehabilitation programs to help improve function while reducing the progression of MKOA. The goal of the proposed work is to understand how quadriceps strength, knee stiffness, proprioception and instability contribute to disease progression and if medial muscle co-contraction is a strategy that will reduce or exacerbate the progression of OA. The knowledge gained in the study will allow us to understand which modifiable characteristics (knee stiffness and instability, and medial muscle co-contraction) will improve knee function without further joint damage and to develop screening tools that properly identify patients who will benefit from the rehabilitation programs. Dr. Buchanan will serve as scientific mentor and Dr. Snyder-Mackler will be career mentor.