KNEE STIFFNESS, PROPRIOCEPTION AND INSTABILITY AFFECT KNEE CONTROL IN OA

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 大量研究表明，膝关节内侧骨关节炎 (MKOA) 患者的股四头肌力量通常较弱，膝关节内收力矩过大，内侧关节过度松弛，所有这些都会导致膝关节软骨受到侵蚀。 然而，除了股四头肌强化计划外，还缺乏能够显着改善关节功能的康复策略。这项工作的长期目标是开发针对患者的康复计划，以帮助改善功能，同时减少 MKOA 的进展。 拟议工作的目标是了解股四头肌力量、膝关节僵硬、本体感觉和不稳定性如何导致疾病进展，以及内侧肌肉共同收缩是否是一种减少或加剧 OA 进展的策略。 研究中获得的知识将使我们能够了解哪些可改变的特征（膝关节僵硬和不稳定性以及内侧肌肉共同收缩）将改善膝关节功能而不会进一步损伤关节，并开发筛选工具来正确识别将从康复计划中受益的患者。 布坎南博士将担任科学导师，斯奈德-麦克勒博士将担任职业导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A myriad of studies have identified that people with medial knee OA (MKOA) typically have weak quadriceps femoris muscles, excessive knee adduction moments and excessive mediolateral joint laxity all of which can contribute to erosion of cartilage in the knee. However, other than quadriceps strengthening programs, there is a dearth of rehabilitation strategies that have shown marked improvement of joint function. The long term goal of this work is to develop patient specific rehabilitation programs to help improve function while reducing the progression of MKOA. The goal of the proposed work is to understand how quadriceps strength, knee stiffness, proprioception and instability contribute to disease progression and if medial muscle co-contraction is a strategy that will reduce or exacerbate the progression of OA. The knowledge gained in the study will allow us to understand which modifiable characteristics (knee stiffness and instability, and medial muscle co-contraction) will improve knee function without further joint damage and to develop screening tools that properly identify patients who will benefit from the rehabilitation programs. Dr. Buchanan will serve as scientific mentor and Dr. Snyder-Mackler will be career mentor.