KNEE STIFFNESS, PROPRIOCEPTION AND INSTABILITY AFFECT KNEE CONTROL IN OA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 大量研究表明，内侧膝关节骨性关节炎(MKOA)患者股四头肌无力，膝关节内收力矩过大，内侧关节过度松弛，所有这些都会导致膝关节软骨的侵蚀。然而，除了股四头肌强化计划外，还缺乏显示关节功能明显改善的康复策略。这项工作的长期目标是开发针对患者的康复计划，以帮助改善功能，同时减少MKOA的进展。这项拟议工作的目标是了解股四头肌力量、膝关节僵硬、本体感觉和不稳定是如何导致疾病进展的，以及内侧肌肉共同收缩是否是一种将减缓或加剧OA进展的策略。研究中获得的知识将使我们了解哪些可修改的特征(膝关节僵硬和不稳定，以及内侧肌肉共同收缩)将在不进一步损害关节的情况下改善膝关节功能，并开发适当识别将从康复计划中受益的患者的筛查工具。布坎南博士将担任科学导师，斯奈德-麦克勒博士将担任职业导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A myriad of studies have identified that people with medial knee OA (MKOA) typically have weak quadriceps femoris muscles, excessive knee adduction moments and excessive mediolateral joint laxity all of which can contribute to erosion of cartilage in the knee. However, other than quadriceps strengthening programs, there is a dearth of rehabilitation strategies that have shown marked improvement of joint function. The long term goal of this work is to develop patient specific rehabilitation programs to help improve function while reducing the progression of MKOA. The goal of the proposed work is to understand how quadriceps strength, knee stiffness, proprioception and instability contribute to disease progression and if medial muscle co-contraction is a strategy that will reduce or exacerbate the progression of OA. The knowledge gained in the study will allow us to understand which modifiable characteristics (knee stiffness and instability, and medial muscle co-contraction) will improve knee function without further joint damage and to develop screening tools that properly identify patients who will benefit from the rehabilitation programs. Dr. Buchanan will serve as scientific mentor and Dr. Snyder-Mackler will be career mentor.