STRUCTURAL STUDIES OF N EUROPEA RH

北欧 RH 的结构研究

• 批准号: 7722085
• 负责人: Michael K Chan
• 金额: $ 0.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722085
• 关键词: Ammonia; Blood; Carbon Dioxide; Computer Retrieval of Information on Scientific Projects Database; Distant; Funding; Goals; Grant; Homologous Gene; Institution; Integral Membrane Protein; Laboratories; Lead; Methylamines; Phenotype; Proteins; Research; Research Personnel; Resources; Role; Source; Structure; United States National Institutes of Health; methylamine; protein structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rh proteins are integral membrane proteins whose most visible role is as a blood factor that determines the (+/-) phenotype of blood (e.g. O+, O-). Recent functional studies by the Kustu laboratory has shown that Rh proteins are CO2 channels. While the structure of two distant homologs, AmtB and Amt-1, have been determined, these Amt proteins are ammonia and/or methylamine channels. The goals of this project are to determine the structure of the first Rh structure protein and to elucidate the features that lead to their distinct functions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Rh蛋白是整合的膜蛋白，其最明显的作用是作为决定血液（+/-）表型（例如O+、O-）的血液因子。Kustu实验室最近的功能研究表明，Rh蛋白是CO2通道。虽然已经确定了两个远缘同源物AmtB和AmtB-1的结构，但这些AmtB蛋白是氨和/或甲胺通道。该项目的目标是确定第一个Rh结构蛋白的结构，并阐明导致其独特功能的特征。