ALTERATIONS IN LIVER, MUSCLE, AND ADIPOSE TISSUE INSULIN SENSITIVITY
ALTERATIONS IN LIVER, MUSCLE, AND ADIPOSE TISSUE INSULIN SENSITIVITY
批准号:
7721456
负责人:
Dominic N Reeds
金额:
$0.61万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-02-01 至 2009-01-31
关键词:
Adipose tissueComputer Retrieval of Information on Scientific Projects DatabaseDoseDyslipidemiasFundingGlucoseGrantHIVHIV InfectionsInfusion proceduresInstitutionInsulinInsulin ResistanceInterleukin-6LabelLipolysisLiverMuscleN(delta)-acetylornithine, -isomerN-dodecanoylglutamic acid, -isomer, sodium saltOrganPalmitatesPathogenesisPatientsPlasmaRateRelative (related person)ResearchResearch PersonnelResourcesSkeletal MuscleSourceStagingTracerTriglyceridesUnited States National Institutes of Healthadipokinesadiponectinalpha-difluoromethyl-DOPA, -isomeralpha-methylornithine dihydrochloride, -isomerglucose disposalglucose productionhealthy volunteerinsulin sensitivitymen
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia. Dyslipidemia is common in patients with HIV infection. In this study, a two-stage euglycemic, hyperinsulinemic clamp, with infusion of stable isotopically labeled tracers, was used to evaluate insulin action in skeletal muscle, liver and adipose tissue in HIV-infected men with dyslipidemia (HIV-DL; plasma triglyceride >250mg/dl and HDL<45mg/dl; n=12), HIV-infected men without dyslipidemia (HIV w/o DL; n=12), and healthy men (n=6). Basal rates of glucose production (glucose Ra), glucose disposal (glucose Rd), and lipolysis (palmitate Ra) were similar between groups. The relative suppression of glucose Ra (63¿4%, 77¿2%, and 78¿3%; P=0.008) and palmitate Ra (49¿4%, 63¿3%, and 68¿3%; P=0.005) during low-dose insulin infusion (plasma insulin=30 ¿U/ml), and the relative stimulation of glucose Rd (214¿21%, 390¿25% and 393¿46%; P=0.001) during high-dose insulin infusion (plasma insulin=75¿U/ml) were lower in HIV-DL than in HIV w/o DL and healthy volunteers, respectively. Suppression of basal glucose Ra correlated with plasma adiponectin (r =0.44, P=0.02), and inversely with plasma interleukin-6 (r =-0.49, P<0.001). Stimulation of glucose Rd correlated directly with adiponectin (r=0.48, P<0.01) and inversely with IL-6 (r=-0.49, P=0.02). We conclude that dyslipidemia in HIV-infected men is indicative of multi-organ insulin resistance, and circulating adipokines may be important in the pathogenesis of impaired insulin action.
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Washington University Institute of Clinical and Translational Sciences (KL2)
-
批准号:10556451
-
项目类别:
-
资助金额:$140.02万
-
财政年份:2017
-
负责人:Dominic N Reeds
-
依托单位:
Washington University Institute of Clinical and Translational Sciences (KL2)
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批准号:10598609
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项目类别:
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资助金额:$140.02万
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财政年份:2017
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负责人:Dominic N Reeds
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依托单位:
TAUROURSODEOXYCHOLIC ACID FOR PROTEASE-INHIBITOR ASSOCIATED INSULIN RESISTANCE
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批准号:8603480
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项目类别:
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资助金额:$33.06万
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财政年份:2013
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负责人:Dominic N Reeds
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依托单位:
TAUROURSODEOXYCHOLIC ACID FOR PROTEASE-INHIBITOR ASSOCIATED INSULIN RESISTANCE
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批准号:8677885
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项目类别:
-
资助金额:$33.06万
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财政年份:2013
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负责人:Dominic N Reeds
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依托单位:
EXERCISE TRAINING AUGMENTS THE PERIPHERAL INSULIN SENSITIZING EFFECTS
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批准号:8361446
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项目类别:
-
资助金额:$2.2万
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财政年份:2011
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负责人:Dominic N Reeds
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依托单位:
WHOLE-BODY PROTEOLYSIS RATE IS ELEVATED IN HIV-ASSOCIATED INSULIN RESISTANCE
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批准号:7721508
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项目类别:
-
资助金额:$0.48万
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财政年份:2008
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负责人:Dominic N Reeds
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依托单位:
ACUTE AND CHRONIC CALORIE RESTRICTION AND THE METABOLIC SYNDROME
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批准号:7603340
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项目类别:
-
资助金额:$1.06万
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财政年份:2007
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负责人:Dominic N Reeds
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依托单位:
AUTONOMIC NERVOUS SYSTEM ACTIVITY IN HIV
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批准号:7603358
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项目类别:
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资助金额:$2.97万
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财政年份:2007
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负责人:Dominic N Reeds
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依托单位:
ALTERATIONS IN LIVER, MUSCLE, AND ADIPOSE TISSUE INSULIN SENSITIVITY
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批准号:7355257
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项目类别:
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资助金额:$1.39万
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财政年份:2006
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负责人:Dominic N Reeds
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依托单位:
ACUTE AND CHRONIC CALORIE RESTRICTION AND THE METABOLIC SYNDROME
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批准号:7377228
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项目类别:
-
资助金额:$21.82万
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财政年份:2006
-
负责人:Dominic N Reeds
-
依托单位:
AUTONOMIC NERVOUS SYSTEM ACTIVITY IN HIV
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批准号:7377245
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项目类别:
-
资助金额:$0.21万
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财政年份:2006
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负责人:Dominic N Reeds
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依托单位:
ALTERATIONS IN LIPID KINETICS IN MEN W/ HIV DYSLIPIDEMIA
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批准号:7180120
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项目类别:
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资助金额:$2.71万
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财政年份:2005
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负责人:Dominic N Reeds
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依托单位:
CALORIC RESTRICTION AND INSULIN ACTION
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批准号:7198744
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项目类别:
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资助金额:$2.22万
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财政年份:2005
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负责人:Dominic N Reeds
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依托单位:
Effect of Korean Ginseng and Ginsenocide RE on Insulin Sensitivity
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批准号:6971991
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项目类别:
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资助金额:$3.48万
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财政年份:2004
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负责人:Dominic N Reeds
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依托单位:
Metabolic Abnormalities in HIV
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批准号:7080413
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项目类别:
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资助金额:$11.31万
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财政年份:2004
-
负责人:Dominic N Reeds
-
依托单位:
Metabolic Abnormalities in HIV
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批准号:7472355
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项目类别:
-
资助金额:$11.18万
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财政年份:2004
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负责人:Dominic N Reeds
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依托单位:
Metabolic Abnormalities in HIV
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批准号:7256301
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项目类别:
-
资助金额:$11.25万
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财政年份:2004
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负责人:Dominic N Reeds
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依托单位:
Metabolic Abnormalities in HIV
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批准号:6920660
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项目类别:
-
资助金额:$11.37万
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财政年份:2004
-
负责人:Dominic N Reeds
-
依托单位:
Metabolic Abnormalities in HIV
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批准号:6712199
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项目类别:
-
资助金额:$11.4万
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财政年份:2004
-
负责人:Dominic N Reeds
-
依托单位:
ALTERATIONS IN LIPID KINETICS IN MEN W/ HIV DYSLIPIDEMIA
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批准号:6977109
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项目类别:
-
资助金额:$1.6万
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财政年份:2003
-
负责人:Dominic N Reeds
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依托单位: