AUTONOMIC NERVOUS SYSTEM ACTIVITY IN HIV

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 高效抗逆转录病毒疗法(HAART)大大降低了艾滋病毒感染患者的死亡率。50%的接受治疗的患者(5；6)出现血脂异常(血浆甘油三酯25omg/dl，高密度脂蛋白45 mg/dl；HIV-DL)，这降低了人们对HAART益处的最初热情。虽然HAART的使用是发生血脂异常的危险因素，但据报道，在获得抗逆转录病毒药物之前，艾滋病毒感染患者的血浆甘油三酯水平较高。未经治疗的艾滋病毒感染通常伴随着不受HAART影响的脂解率升高。这很可能是由于脂解率升高导致的FFA供应增加导致了HIV感染患者的血脂异常。交感神经系统(SNS)模拟生理应激期间的脂解作用，我们发现HIV-血脂异常患者的血浆儿茶酚胺水平升高。一些小规模的研究表明，HIV感染者的SNS活性升高。在几项研究中观察到的副交感神经系统活动减少也可能导致脂肪分解面积的增加。尽管有证据表明未经治疗的艾滋病毒感染患者的自主神经功能异常，但尚未有研究系统地评估未经治疗的艾滋病毒感染患者的SNS和PNS活性，以及ANS活性与脂代谢的关系。在这项研究中，我们建议系统地测量未经治疗的HIV感染患者和健康志愿者在基础状态和注射心得安期间的自主神经系统活动和脂解率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Highly-active antiretroviral therapy (HAART) has dramatically reduced mortality rates in patients with HIV infection. Initial enthusiasm for the benefits of HAART has been tempered by the occurrence of dyslipidemia (plasma triglyceride >25omg/dl, HDL <45 mg/dl; HIV-DL) in ? 50% of treated patients (5;6). While HAART use is a risk factor for development of dyslipidemia, high plasma triglycerides were reported in patients with HIV infection prior to the availability of antiretroviral medications. Untreated HIV infection is often accompanied by elevated lipolytic rate that is unaffected by HAART. It is likely that increased FFA supply due to elevated lipolytic rate contributes to dyslipidemia in patients with HIV infection. The sympathetic nervous system (SNS) simulates lipolysis during periods of physiologic stress, and we have found that plasma catecholamines are elevated in patients with HIV-dyslipidemia. Several small studies have suggested that patients with HIV infection have elevated SNS activity. Reduced parasympathetic nervous system activity, which has been observed in several studies, could also contribute to elevated areas of lipolysis. Despite evidence of abnormalities in autonomic function in patients with untreated HIV infection, no study has systematically evaluated SNS and PNS activity in patients with untreated HIV infection, and the relationship between ANS activity and lipid metabolism. In this study we propose to systematically measure autonomic nervous system activity and to evaluate lipolytic rate during basal conditions, and during infusion of propanolol, in patients with untreated HIV infection, and in healthy volunteers.