EXERCISE TRAINING AUGMENTS THE PERIPHERAL INSULIN SENSITIZING EFFECTS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 背景胰岛素抵抗和2型糖尿病（DM）的患病率和发病率在接受人类免疫缺陷病毒-1（HIV）感染治疗的人群中高于一般人群。确定安全和有效的干预措施是一个高度优先事项。Objective.我们评估了在伴有胰岛素抵抗和中枢性肥胖的HIV感染成人中，过氧化物酶体增殖物激活受体-γ激动剂吡格列酮与运动训练相比是否能更好地改善中枢和外周胰岛素敏感性。设计44名基线胰岛素抵抗和中心性肥胖的HIV感染成人被随机分配到4个月的吡格列酮（30 mg/d），有或没有监督，渐进式有氧运动和阻力运动训练（11/2 - 2小时/天，3天/周）。采用高胰岛素-正葡萄糖钳夹技术评价中枢和外周胰岛素敏感性的改变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background. The prevalence and incidence of insulin resistance and type 2 diabetes (DM) are higher in people treated for human immunodeficiency virus-1 (HIV) infection than in the general population. Identifying safe and effective interventions is a high priority. Objective. We evaluated whether the peroxisome proliferator activated receptor-gamma agonist pioglitazone with exercise training improves central and peripheral insulin sensitivity more than pioglitazone alone in HIV infected adults with insulin resistance and central adiposity. Design. Forty-four HIV infected adults with baseline insulin resistance and central adiposity were randomly assigned to 4-months of pioglitazone (30mg/d) with or without supervised, progressive aerobic and resistance exercise training (11/2 -2 hr/d, 3 days/wk). The hyperinsulinemic-euglycemic clamp was used to evaluate alterations in central and peripheral insulin sensitivity.