EXERCISE TRAINING AUGMENTS THE PERIPHERAL INSULIN SENSITIZING EFFECTS

运动训练增强外周胰岛素增敏作用

• 批准号: 8361446
• 负责人: Dominic N Reeds
• 金额: $ 2.2万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361446
• 关键词: Adult; Aerobic; Agonist; Euglycemic Clamping; Exercise; Funding; General Population; Glucose Clamp; Grant; HIV-1; Incidence; Infection; Insulin; Insulin Resistance; Mass Spectrum Analysis; National Center for Research Resources; Non-Insulin-Dependent Diabetes Mellitus; Obesity; PPAR gamma; Peripheral; Pioglitazone; Prevalence; Principal Investigator; Randomized; Research; Research Infrastructure; Resistance; Resources; Source; Training; United States National Institutes of Health; biomedical resource; cost; design; effective intervention; improved; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background. The prevalence and incidence of insulin resistance and type 2 diabetes (DM) are higher in people treated for human immunodeficiency virus-1 (HIV) infection than in the general population. Identifying safe and effective interventions is a high priority. Objective. We evaluated whether the peroxisome proliferator activated receptor-gamma agonist pioglitazone with exercise training improves central and peripheral insulin sensitivity more than pioglitazone alone in HIV infected adults with insulin resistance and central adiposity. Design. Forty-four HIV infected adults with baseline insulin resistance and central adiposity were randomly assigned to 4-months of pioglitazone (30mg/d) with or without supervised, progressive aerobic and resistance exercise training (11/2 -2 hr/d, 3 days/wk). The hyperinsulinemic-euglycemic clamp was used to evaluate alterations in central and peripheral insulin sensitivity.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景资料。在接受人类免疫缺陷病毒-1(HIV)感染治疗的人中，胰岛素抵抗和2型糖尿病(DM)的患病率和发病率高于普通人群。确定安全有效的干预措施是一个高度优先事项。目标。我们评估了在患有胰岛素抵抗和中心性肥胖症的HIV感染者中，运动训练联合使用过氧化体增殖物激活受体-γ激动剂吡格列酮是否比单独使用吡格列酮更能改善中枢和外周胰岛素敏感性。设计。44例有胰岛素抵抗和中心性肥胖的HIV感染者被随机分配到4个月的吡格列酮(30 mg/d)治疗中，同时接受或不接受有监督的渐进性有氧和阻力运动训练(11/2-2小时/d，3天/wk)。用高胰岛素-正常血糖钳夹检测中枢和外周胰岛素敏感性的变化。