NATURAL PRODUCT SYNTHESIS AND CHEMICAL BIOLOGY OF NOVEL SKELETAL STRUCTURES

新型骨骼结构的天然产物合成和化学生物学

• 批准号: 7721493
• 负责人: CHUO CHEN
• 金额: $ 0.06万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721493
• 关键词: Biological; Biological Factors; Biology; Catalysis; Chemicals; Collection; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Delivery Systems; Funding; Grant; Institution; Laboratories; Organic Chemistry; Pharmaceutical Preparations; Property; Research; Research Personnel; Resources; Screening procedure; Skeletal system; Source; Structure; System; Transition Elements; United States National Institutes of Health; chemical synthesis; interest; novel; programs; protein function; small molecule; small molecule libraries; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The research interests of my laboratory are in the field of natural product synthesis and chemical biology. Specifically, synthesis of natural products with novel skeletal structures and intriguing biological properties is the focus of our research program. New synthetic tools, such as novel asymmetric organocatalysis and transition metal catalysis, will also be developed to advance current synthetic organic chemistry. These natural products and structurally sophisticated synthetic intermediates will be used to study their mode of action in cellular systems. The other focus of our research program is synthesis of large collections of natural product-like small molecules. High-throughput biological screening of these small molecule libraries will be carried out to identify compounds that can be used to study protein functions. The chemical biology information obtained from these two approaches will also be used to identify new drug targets and drug leads for various diseases.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我的实验室的研究兴趣是天然产物合成和化学生物学领域。具体地说，合成具有新颖骨架结构和耐人寻味的生物学特性的天然产物是我们研究计划的重点。还将开发新的合成工具，如新型不对称有机催化和过渡金属催化，以促进当前合成有机化学的发展。这些天然产物和结构复杂的合成中间体将用于研究它们在细胞系统中的作用模式。我们研究计划的另一个重点是合成大量的天然产物类小分子。将对这些小分子文库进行高通量生物筛选，以确定可用于研究蛋白质功能的化合物。从这两种方法获得的化学生物学信息也将用于确定各种疾病的新药物靶点和药物先导。