Asymmetric Synthesis of Biologically Active Marine Natural Products

描述(申请人提供)：研究天然产物的合成为确定化学和生物学的新方向提供了丰富的机会。我们研究计划的总体目标是研究与药物相关的小分子的化学合成，并为下一代药物合成推进化学技术。通过这个项目，我们将更好地了解自然界是如何进行环加成类型的二聚反应来生成更高阶吡咯-咪唑生物碱的。我们将测试生物合成假说，并开发这些天然产物的仿生合成方法。受氧化金属酶的启发，我们将进一步开发用于C-H和烯烃氧化的新型金属催化剂。我们的研究将对小分子药物的发现和制造产生直接影响。

DESCRIPTION (provided by applicant): Studying the synthesis of natural products provides rich opportunities for identifying new directions in chemistry and biology. The overarching goal of our research program is to study the chemical synthesis of small-molecules of medicinal relevance and to advance chemical technology for the next-generation of drug synthesis. Through this project, we will better understand how nature performs cycloaddition-type dimerization reactions to produce higher order pyrrole-imidazole alkaloids. We will test the biosynthetic hypotheses and develop biomimetic synthetic approaches to these natural products. Inspired by the oxidative metalloenzymes, we will further develop new metal catalysts for C-H and olefin oxidation. Our research will have direct impacts on the discovery and manufacturing of small-molecule drugs.