COMPARATIVE GENOMICS OF PEROXISOMAL LIPID METABOLISM

过氧化物酶体脂质代谢的比较基因组学

• 批准号: 7723631
• 负责人: JOSEPH G HACIA
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723631
• 关键词: Africa; Cardiovascular system; Complex; Computer Retrieval of Information on Scientific Projects Database; Consumption; Environment; Funding; Genomics; Grant; Homo; Human; Institution; Lipids; Liver; Meat; Metabolic Pathway; Pathway interactions; Phenotype; Physiological; Research; Research Personnel; Resources; Source; United States National Institutes of Health; base; comparative; lipid metabolism; migration; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Since the emergence of the genus Homo, there have been many significant changes in the interactions of humans and their ancestors with their environments. One such interaction involves dramatic increases in meat consumption prior to migrations of modern humans out of Africa. We hypothesize that humans and their ancestors have acquired adaptive changes in lipid metabolic pathways in response to dietary shifts. Based on the known physiological importance of these pathways, these selective changes could strongly influence complex human phenotypes involving the nervous and cardiovascular systems and liver.

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