COMPARATIVE GENOMICS OF PEROXISOMAL LIPID METABOLISM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 自从人属出现以来，人类及其祖先与环境的相互作用发生了许多重大变化。其中一个相互作用涉及现代人类迁出非洲之前肉类消费的急剧增加。我们推测，人类及其祖先已经获得了适应性变化的脂质代谢途径，以应对饮食的变化。基于这些途径的已知生理重要性，这些选择性变化可能强烈影响涉及神经和心血管系统以及肝脏的复杂人类表型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Since the emergence of the genus Homo, there have been many significant changes in the interactions of humans and their ancestors with their environments. One such interaction involves dramatic increases in meat consumption prior to migrations of modern humans out of Africa. We hypothesize that humans and their ancestors have acquired adaptive changes in lipid metabolic pathways in response to dietary shifts. Based on the known physiological importance of these pathways, these selective changes could strongly influence complex human phenotypes involving the nervous and cardiovascular systems and liver.