CLINICAL COMPUTATIONAL ANATOMY

临床计算解剖学

• 批准号: 7724768
• 负责人: Ion-Florin Talos
• 金额: $ 52.49万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-22 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724768
• 关键词: Anatomy; Atlases; Brain; Brain Neoplasms; Clinical; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Data Set; Diffusion; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Head; Infiltration; Informatics; Institution; Label; Magnetic Resonance Imaging; Maps; Neuroanatomy; Pathology; Process; Publishing; Purpose; Radiology Specialty; Reporting; Research; Research Personnel; Resolution; Resources; Source; United States National Institutes of Health; Work; digital; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Consistent with the proposed goal of this project to provide a comprehensive reference to neuroanatomy and white matter pathology, during the April 2006-April 2007 reporting period we have completed a quantitative analysis of white matter infiltration by primary brain tumors. The results of this study were published in Academic Radiology in 2007 (Talos et al., 2007). For the purpose of developing a new multi-modal brain atlas, to serve as a reference for normal white matter anatomy, we have recently acquired a new multi-modal, highresolution MRI data set. The acquisition was performed on a 3T Siemens MRI scanner using a 32-channel head coil and includes a 0.5 mm isotropic MPRAGE and a 1 mm isotropic, 128 gradients Diffusion Tensor sequence. Currently, work is under way, in collaboration with the White Matter and fMRI Informatics Cores on two fronts: + mapping the label maps of the original digital brain atlas (SPL-PNL) into the new MRI data set to facilitate segmentation; and + loading and processing a new high-resolution DTI data set (128 gradients) using the 3D-Slicer.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 与本项目提出的目标相一致，提供全面的参考 在2006年4月至2007年4月的报告中， 期间，我们已经完成了白色物质渗透的定量分析， 脑瘤这项研究的结果发表在2007年的《学术放射学》上 （Talos等人，2007年）。 为开发新的多通道脑图谱， 正常的白色物质解剖，我们最近获得了一个新的多模态，高分辨率MRI数据集。在3 T Siemens MRI扫描仪上进行采集 使用32通道头部线圈，并包括0.5 mm各向同性MP3和1 mm 各向同性，128梯度扩散张量序列。目前，工作正在进行中， 与白色物质和功能磁共振成像信息学核心在两个方面的合作： + 将原始数字脑图谱（SPL-PNL）的标签图映射到新的MRI中 数据集，以促进细分;以及 + 加载和处理新的高分辨率DTI数据集（128个梯度）， 3D切片机