ENGINEERING

工程

• 批准号: 7724772
• 负责人: STEVEN PIEPER
• 金额: $ 78.73万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-22 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724772
• 关键词: Acetylcysteine; Algorithms; Clinical Research; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Computer software; Detection; Development; Engineering; Foundations; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Link; Mathematics; Productivity; Purpose; Recording of previous events; Research; Research Personnel; Resources; Science; Source; System; Technology; Time; United States National Institutes of Health; Work; abstracting; computer science; concept; file format; interoperability; outreach; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Engineering Core is to provide a workable and efficient platform to integrate NAC technology into a usable software application in support of our collaborations and outreach activities. This platform provides an essential link between the abstract world of applied mathematics and computer science, where a proof of concept can serve as a powerful research result, and the applied biomedical sciences where robust and usable systems are needed to drive the analysis of multiple subjects in a variety of clinical research scenarios. In particular, the Engineering Core is focused on such issues as interoperability between algorithms developed by the various cores of the NAC so that, for example, an R01 that results from an fMRI activation detection analysis can be used as the seeding points for DTI tractography to identify the white matter connections that may associate the activated R01 with other cortical and subcortical regions. By providing a common platform for research by the multiple cores, the potential value and applicability of each core is multiplied. Beyond functionality, the common platform gives users a common set of interface conventions, file formats, and related application-level support to enhance their productivity. Through the history of the NAC enterprise, our efforts have evolved increasingly towards the 3D Slicer platform as our mechanism for linking the basic computational research with the biomedical applications. 3D Slicer also acts as the conduit for delivering this work to the outside world as part of our outreach activities. This effort has, in fact, been so successful that 3D Slicer has in some sense "graduated" from the NAC to become an important part of several large NIH sponsored efforts including the NA-MIC, BIRN, and NCIGT efforts. This gratifying development increases the scope of the development activities beyond what NAC alone could provide and at the same time strengthens the foundations of the software.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 工程核心的目的是提供一个可行和有效的平台， 将NAC技术集成到可用软件应用程序中， 协作和外联活动。这个平台提供了一个重要的联系， 在应用数学和计算机科学的抽象世界中， 概念可以作为一个强大的研究成果，应用生物医学科学 其中需要强大且可用的系统来驱动对各种临床研究场景中的多个受试者的分析。特别是，工程核心集中在这样的问题，如由NAC的各种核心开发的算法之间的互操作性，以便，例如，从功能磁共振成像激活检测分析结果的R 01可以被用作DTI纤维束成像的播种点，以识别白色物质连接，可能与其他皮层和皮层下区域激活的R 01。通过为多个核心的研究提供一个共同的平台，每个核心的潜在价值和适用性成倍增加。 除了功能之外，通用平台还为用户提供了一组通用的界面 约定、文件格式和相关的应用程序级支持， 生产力通过南汽企业的历史，我们的努力不断发展 我们越来越倾向于将3D Slicer平台作为我们连接基本 计算研究与生物医学应用。3D Slicer还充当 作为我们对外宣传活动的一部分，我们还将作为一个渠道向外部世界提供这项工作。 事实上，这一努力非常成功，3D Slicer在某种意义上已经从NAC“毕业”，成为NIH赞助的几个大型项目的重要组成部分，包括NA-MIC、BIRN和NCIGT项目。这一令人满意的发展扩大了开发活动的范围，超出了NAC单独能够提供的范围，同时加强了软件的基础。