SPL ENGINEERING CORE (FORMERLY THE BIRN SUBPROJECT)

SPL 工程核心（以前的 BIRN 子项目）

• 批准号: 7182663
• 负责人: STEVEN PIEPER
• 金额: $ 86.62万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7182663
• 关键词: clinical research; neuroimaging

DESCRIPTION (provided by applicant): The Neuroimaging Analysis Center (NAC) is a National Research Resource Center operating in an application-oriented, clinical environment with the mission of focused computer-science based technology research and development. This proposal represents a continuation and expansion of ongoing efforts, with a shift in focus from generic image analysis capabilities to neuroimage informatics techniques tightly coupled to support particular applications. These neuroscientific and clinical applications provide demanding neuroimage informatics challenges which require new technology research and development, which, when solved, will have widespread applicability. The proposed core activities include algorithm development for the analysis of white matter architecture using diffusion tensor MRI and characterization of the spatial and temporal development of the structures in the infant brain, as well as the development of image informatics tools that are aimed at facilitating the exploitation of fMRI-derived information in neurosurgical and neuroscientific applications. In addition, novel methods of medical image representation and visualization will be explored and developed, as well as a new multi-modal digital anatomical atlas. The incorporation of Biomedical Informatics Research Network (BIRN) activities will accomplish the centralization of engineering efforts (facilitating better utilization of engineering resources) and will enable the provision of a hardware and software infrastructure to support increasingly large and complex data sets. NAC will continue to be a Resource for collaborative projects, service, and training. The Technology Research and Development Core subprojects are closely linked with a variety of collaborative studies, and additional collaborators are engaged and facilitated directly by our primary collaborators. Service projects consist primarily of downloads and support of application software and anonymous data sets from the NAC web site. Training is available for scientists at both the undergraduate and post-graduate levels, and is offered in both medical and engineering contexts. The NAC will provide a vehicle for the dissemination of the results of the proposed work to the lar#1er research and clinical communities.

描述（由申请人提供）： 神经影像分析中心（NAC）是一个国家研究资源中心，在面向应用的临床环境中运作，其使命是专注于基于计算机科学的技术研究和开发。该提案代表了正在进行的努力的延续和扩展，重点从通用图像分析能力转移到紧密耦合以支持特定应用的神经图像信息学技术。这些神经科学和临床应用提供了要求苛刻的神经图像信息学挑战，需要新技术的研究和开发，当解决时，将具有广泛的适用性。拟议的核心活动包括使用扩散张量MRI分析白色物质结构的算法开发和婴儿大脑结构的空间和时间发展的表征，以及开发图像信息学工具，旨在促进在神经外科和神经科学应用中利用功能性MRI衍生的信息。此外，将探索和开发医学图像表示和可视化的新方法，以及新的多模态数字解剖图谱。纳入生物医学信息学研究网络（BIRN）活动将实现工程工作的集中化（促进更好地利用工程资源），并将能够提供硬件和软件基础设施，以支持日益庞大和复杂的数据集。NAC将继续成为合作项目、服务和培训的资源。技术研究和开发核心子项目与各种合作研究密切相关，我们的主要合作者直接参与并促进了其他合作者。服务项目主要包括从国家行动委员会网站下载和支持应用软件和匿名数据集。培训可在本科和研究生水平的科学家，并在医学和工程背景下提供。NAC将提供一个工具，用于向lar#1er研究和临床社区传播拟议工作的结果。