ENGINEERING

工程

• 批准号: 7602394
• 负责人: STEVEN PIEPER
• 金额: $ 57.75万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602394
• 关键词: Acetylcysteine; Algorithms; Clinical Research; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Computer software; Detection; Development; Engineering; Foundations; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Link; Mathematics; Productivity; Purpose; Recording of previous events; Research; Research Personnel; Resources; Science; Source; System; Technology; Time; United States National Institutes of Health; Work; abstracting; computer science; concept; file format; interoperability; outreach; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Engineering Core is to provide a workable and efficient platform to integrate NAC technology into a usable software application in support of our collaborations and outreach activities. This platform provides an essential link between the abstract world of applied mathematics and computer science, where a proof of concept can serve as a powerful research result, and the applied biomedical sciences where robust and usable systems are needed to drive the analysis of multiple subjects in a variety of clinical research scenarios. In particular, the Engineering Core is focused on such issues as interoperability between algorithms developed by the various cores of the NAC so that, for example, an R01 that results from an fMRI activation detection analysis can be used as the seeding points for DTI tractography to identify the white matter connections that may associate the activated R01 with other cortical and subcortical regions. By providing a common platform for research by the multiple cores, the potential value and applicability of each core is multiplied. Beyond functionality, the common platform gives users a common set of interface conventions, file formats, and related application-level support to enhance their productivity. Through the history of the NAC enterprise, our efforts have evolved increasingly towards the 3D Slicer platform as our mechanism for linking the basic computational research with the biomedical applications. 3D Slicer also acts as the conduit for delivering this work to the outside world as part of our outreach activities. This effort has, in fact, been so successful that 3D Slicer has in some sense graduated from the NAC to become an important part of several large NIH sponsored efforts including the NA-MIC, BIRN, and NCIGT efforts. This gratifying development increases the scope of the development activities beyond what NAC alone could provide and at the same time strengthens the foundations of the software.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 工程核心的目的是提供一个可行且高效的平台 将NAC技术集成到可用的软件应用程序中，以支持我们的 合作和外联活动。该平台在以下方面提供了重要的联系 应用数学和计算机科学的抽象世界，在那里证明 概念可以作为一个强大的研究成果，而应用生物医学科学 在各种临床研究场景中，需要强大和可用的系统来推动对多个对象的分析。具体而言，工程核心侧重于由NAC的各种核心开发的算法之间的互操作性等问题，因此，例如，从功能磁共振激活检测分析得到的R01可以被用作DTI脑束成像的种子点，以识别可能将激活的R01与其他皮质和皮质下区域相关联的白质连接。通过为多个核的研究提供公共平台，每个核的潜在价值和适用性成倍增加。 除了功能之外，通用平台还为用户提供了一套通用的界面 约定、文件格式和相关的应用程序级支持，以增强其 生产力。通过南汽企业的历史，我们的努力已经演变 越来越多地将3D Slicer平台作为我们连接基本 生物医学应用中的计算研究。3D Slicer还充当 作为我们外联活动的一部分，向外界提供这项工作的渠道。 事实上，这项工作非常成功，从某种意义上说，3D Slicer已经从NAC毕业，成为NIH赞助的几个大型项目的重要组成部分，包括NA-MIC、BIRN和NCIGT。这一令人欣慰的发展扩大了开发活动的范围，超出了NAC本身所能提供的范围，同时加强了软件的基础。