ASSOCIATIVE RETRIEVAL AND MISMATCH SIGNALS IN THE CA FIELDS OF HUMAN HIPPOCAMPUS

人类海马 CA 区的联想检索和失配信号

• 批准号: 7722922
• 负责人: JANICE CHEN
• 金额: $ 0.28万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722922
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cues; Detection; Elements; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampus (Brain); Housing; Human; Institution; Knowledge; Measures; Memory; Methods; Output; Pattern; Personal Satisfaction; Positioning Attribute; Research; Research Personnel; Resolution; Resources; Retrieval; Role; Scanning; Sensory; Signal Transduction; Source; Thinking; United States National Institutes of Health; base; dentate gyrus; entorhinal cortex; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While the role of the hippocampus in declarative memory is well established, the mechanisms subserved by component subfields remain underspecified. Within the hippocampuswhich includes dentate gyrus, CA3, CA1, and subiculumit has been hypothesized that CA3 and CA1 differentially support memory-based associative predictions and the detection of associative prediction error. From this perspective, CA3 is posited to encode conjunctive memories that are subsequently "pattern completed" during associative retrieval, in essence making predictions about the present based on associative knowledge acquired in the past. CA3 is thought to pass these predictions to CA1, which is positioned to compare this output from memory with input from entorhinal cortex that transmits the present state of "sensory reality". Specific Aims: We seek to examine the functional contributions of human CA3 and CA1 to associative retrieval and the detection of associative prediction error. Methods and Materials: We used high-resolution fMRI to measure the functional response of MTL corticesperirhinal, parahippocampal, and entorhinaland the subfields of hippocampus. Subjects encoded face-house pairs, and were subsequently scanned at 3T while performing cued-recall followed by a match/mismatch probe decision. On each recall trial, one element of a studied pair served as the retrieval cue, which was followed by a 7.5-s delay during which the subject attempted to retrieve the associate. Following the delay, a probe was presented¿either the correct associate (match) or an incorrect item (mismatch); subjects had 750 ms to respond.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 虽然海马体在陈述性记忆中的作用已经很好地建立，但组件子字段所服务的机制仍然不明确。在海马体中包括齿状回、CA 3、CA 1和下托假设CA 3和CA 1不同地支持基于存储器的关联预测和关联预测误差的检测。从这个角度来看，CA 3被假定为编码随后在联想检索期间“模式完成”的连接记忆，本质上是基于过去获得的联想知识对现在进行预测。CA 3被认为将这些预测传递给CA 1，CA 1被定位为将来自记忆的输出与来自内嗅皮层的输入进行比较，内嗅皮层传输“感觉现实”的当前状态。 具体目标：我们试图研究人类CA 3和CA 1的功能贡献的联想检索和检测的联想预测错误。 方法和材料：我们使用高分辨率fMRI测量MTL皮质的功能反应嗅周、海马旁和内嗅和海马体的子区域。受试者编码的脸房子对，随后在3 T扫描，同时进行线索回忆，然后由匹配/不匹配的探针决定。在每次回忆试验中，一个元素的研究对作为检索线索，这是由7.5秒的延迟，在此期间，受试者试图检索的关联。在延迟之后，¿正确的关联（匹配）或不正确的项目（不匹配）;受试者有750 ms的响应时间。