DEFAULT-MODE FUNCTION AND TASK-INDUCED DEACTIVATION IN CHILDREN
DEFAULT-MODE FUNCTION AND TASK-INDUCED DEACTIVATION IN CHILDREN
批准号:
7722896
负责人:
Moriah E Thomason
金额:
$1.12万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-06-01 至 2009-05-31
关键词:
12 year oldAdultBrainChildCognitiveComputer Retrieval of Information on Scientific Projects DatabaseConditionFundingGrantIndividualInstitutionNaturePaperPurposeResearchResearch PersonnelResourcesRestSignal TransductionSourceStructureTestingUnited States National Institutes of Healthblood oxygen level dependentindependent component analysisinsightrelating to nervous systemresponse
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Introduction: The regions that comprise the functionally connected resting-state default-mode network (DMN) in adults appear to be the same as those that are characterized by task-induced decreases in blood-oxygen-level-dependent (BOLD) signal. Independent component analysis can be used to produce a picture of the DMN as an individual rests quietly in the scanner. Contrasts across conditions in which cognitive load is parametrically modulated can delineate neural structures that have decreases in activation in response to high-demand task conditions. Examination of the degree to which these networks subsume dissociable brain substrates, and of the degree to which they overlap, provides insight concerning their purpose, function, and the nature of their associations. Few studies have examined the DMN in children, and none have tested whether the neural regions that comprise the DMN during a resting condition are the same regions that show reduced activity when children engage in cognitive tasks.
Specific Aims: In this paper we describe regions that show both task-related decreases and spontaneous intrinsic activity at rest in children, and we examine the co-localization of these networks. We describe ways in which the DMN in 7-12-year-old children is both similar to and different from the DMN in adults; moreover, we document that task-induced deactivations and default-mode resting-state activity in children share common neural substrates.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
In utero Assessment of the Human Neural Connectome and Later Child Behavior
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批准号:9170791
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项目类别:
-
资助金额:$52.15万
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财政年份:2016
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负责人:Moriah E Thomason
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依托单位:
Developmental effects of 5-HTT genotype on stress reactivity and brain function
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批准号:7616242
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项目类别:
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资助金额:$5.01万
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财政年份:2008
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负责人:Moriah E Thomason
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依托单位:
Developmental effects of 5-HTT genotype on stress reactivity and brain function
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批准号:7487153
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项目类别:
-
资助金额:$4.68万
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财政年份:2008
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负责人:Moriah E Thomason
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依托单位:
Developmental effects of 5-HTT genotype on stress reactivity and brain function
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批准号:7799722
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项目类别:
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资助金额:$4.85万
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财政年份:2008
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负责人:Moriah E Thomason
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依托单位:
LATERALIZATION OF WORKING MEMORY PROCESSING IN DEVELOPMENT
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批准号:7601903
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项目类别:
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资助金额:$2.3万
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财政年份:2007
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负责人:Moriah E Thomason
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依托单位:
BOLD FMRI RESPONSE IS AN INDIRECT CONSEQUENCE OF CHANGES IN NEURONAL METABOLISM
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批准号:7358764
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项目类别:
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资助金额:$2.49万
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财政年份:2006
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负责人:Moriah E Thomason
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依托单位:
Brain Basis of the Development of Human Working Memory
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批准号:6949114
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项目类别:
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资助金额:$3.48万
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财政年份:2004
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负责人:Moriah E Thomason
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依托单位:
Brain Basis of the Development of Human Working Memory
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批准号:6835338
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项目类别:
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资助金额:$4.91万
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财政年份:2004
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负责人:Moriah E Thomason
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依托单位:
USE OF FMRI TO INVESTIGATE THE NEURAL BASIS OF MEMORY AND EXECUTIVE PROCESSES
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批准号:6978360
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项目类别:
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资助金额:$0.5万
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财政年份:2004
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负责人:Moriah E Thomason
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依托单位:
海外基金