CHANGES IN COLLAGENOUS TISSUE OBSERVED IN VARIOUS CANCERS AS DIAGNOSTIC TOOL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 恶性肿瘤的早期诊断与较好的预后直接相关。然而，对于许多恶性肿瘤来说，还没有现成的、非侵入性的、具有成本效益的诊断测试。患者往往来得太晚，无法进行有效的治疗。我2007年在BioCAT设施进行的研究结果首次表明，使用皮肤或指甲的纤维衍射图案作为生物特征诊断方法来检测肿瘤性或神经系统疾病，包括但不限于乳腺癌、结肠癌和前列腺癌、黑色素瘤和阿尔茨海默病。这些替代组织似乎比早期的头发衍射研究更有希望，因为困扰头发衍射诊断测试的许多混乱问题已经被消除，这些问题是由处理、安装和美容治疗引起的。到目前为止的结果表明，使用一种新开发的和完全不同的实验程序进行的指甲衍射研究，可能会为乳腺癌、结肠癌和阿尔茨海默病提供一种替代的诊断测试。到目前为止，这项皮肤衍射研究揭示了前列腺癌或黑色素瘤的特有变化，这两种癌症都不会导致头发发生任何变化，即使是来自7级癌症患者的样本也是如此。有必要进行更多的测试，以获得统计上可靠的特异性和敏感性，并将研究扩展到其他有希望的肿瘤性疾病。有了这样适当的进一步发展，对这些肿瘤和神经疾病的完全非侵入性但可靠的诊断测试可以定期进行，作为使用同步加速器合适的束线的大规模筛查测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An early diagnosis of malignancies correlates directly with a better prognosis. Yet for many malignancies there are no readily available, non invasive, cost effective diagnostic tests. Too often the patient presents too late for effective treatment. My 2007 results, from research conducted at the BioCAT Facility, have shown for the first time the use of fibre diffraction patterns of skin or nails as a biometric diagnostic method for detecting neoplastic or neurological disorders including but not limited to breast, colon, and prostate cancers, melanoma and Alzheimer's disease. These alternative tissues appear to hold more promise than the earlier hair diffraction study as the many disorder problems, resulting from handling, mounting and cosmetic treatments that have plagued the hair diffraction diagnostic tests, have been eliminated. Results to date show that nail diffraction studies, using a newly developed and quite different experimental procedure, may provide an alternative diagnostic test for breast and colon cancers and Alzheimer's disease. The skin diffraction study has to date revealed "signature changes" specific to the presence of either prostate cancer or melanoma, neither of which cancers caused any change in hair even with samples from patients with Grade 7 cancers. More tests are necessary to obtain statistically reliable specificities and sensitivities and to extend the study to other promising neoplastic diseases. With such suitable further development, a totally non-invasive yet reliable diagnostic test for these neoplastic and neurological diseases could be conducted on a regular basis as a mass screening test using suitable beam-lines at synchrotrons.