VERIFICATION OF DIAGNOSTIC TESTS FOR NEOPLASTIC DISEASES USING SKIN BIOPSIES

使用皮肤活检验证肿瘤疾病的诊断测试

• 批准号: 8168618
• 负责人: VERONICA JAMES
• 金额: $ 2.15万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168618
• 关键词: Alzheimer' s Disease; Biopsy; Colon Carcinoma; Computer Retrieval of Information on Scientific Projects Database; Cutaneous Melanoma; Diagnosis; Diagnostic tests; Disease; Double-Blind Method; Early Diagnosis; Funding; Grant; Institution; Lung; Malignant Neoplasms; Malignant neoplasm of prostate; Nail plate; Patients; Pattern; Photons; Punch Biopsy; Research; Research Personnel; Resources; Sampling; Skin; Source; Structure of nail of finger; United States National Institutes of Health; cancer site; malignant breast neoplasm; melanoma; neoplastic; outcome forecast; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although huge advances have been made in the treatment of many neoplastic diseases over the last century, an early diagnosis is essential in most cases for a satisfactory prognosis. Unfortunately reliable diagnostic tests are not yet available for many such diseases. Amongst these are a number of very common, exceedingly aggressive cancers which are far too often terminal at first diagnosis. These Include melanoma, adeno lung and prostate cancer. 264 samples were investigated at the BioCAT Facility, Advanced Photon Source in March 2009 to determine whether any specific changes occurred in the skin adjacent to the cancer site or the nails for each of these cancers. Double-blinded full punch biopsies of skin were used for the skin experiments. Our results confirmed that specific changes did occur in the diffraction pattern of skin for melanoma, adeno lung and prostate cancers as illustrated below for a case where the patient had both melanoma and prostate cancer. Changes in the diffraction pattern for fingernails were also investigated for samples from 50 patients. Clear changes were noted in the diffraction for patients with breast cancer, colon cancer and Alzheimer's' disease confirming earlier preliminary results, but not with any other cancers..

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管在过去的一个世纪里，许多肿瘤性疾病的治疗取得了巨大的进步，但在大多数情况下，早期诊断对于获得满意的预后是必不可少的。不幸的是，目前还没有针对许多此类疾病的可靠诊断测试。在这些癌症中，有一些非常常见、极具侵袭性的癌症，它们在第一次诊断时往往是晚期癌症。这些疾病包括黑色素瘤、肺腺癌和前列腺癌。 2009年3月，在先进光子源的BioCAT设备中对264个样本进行了调查，以确定癌症部位附近的皮肤或指甲是否发生了任何具体的变化。 皮肤实验采用双盲全穿孔皮肤活检方法。我们的结果证实，黑色素瘤、腺肺癌和前列腺癌的皮肤衍射图确实发生了特定的变化，如下所示，患者同时患有黑色素瘤和前列腺癌。 我们还对50名患者的指甲样品的衍射图的变化进行了研究。在乳腺癌、结肠癌和阿尔茨海默病患者的衍射图中注意到了明显的变化，证实了早期的初步结果，但没有与任何其他癌症相一致。