VERIFICATION OF DIAGNOSTIC TESTS FOR NEOPLASTIC DISEASES USING SKIN BIOPSIES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尽管在过去的世纪中，许多肿瘤性疾病的治疗取得了巨大的进步，但在大多数情况下，早期诊断对于令人满意的预后至关重要。不幸的是，许多这类疾病还没有可靠的诊断测试。在这些癌症中，有一些非常常见的、极具侵袭性的癌症，在第一次诊断时往往是晚期。这些包括黑色素瘤、肺腺癌和前列腺癌。 2009年3月，在BioCAT Facility，Advanced Photon Source研究了264个样本，以确定每种癌症的癌症部位或指甲附近的皮肤是否发生任何特定变化。 皮肤的双盲全穿孔活组织检查用于皮肤实验。我们的结果证实，黑色素瘤、肺腺癌和前列腺癌的皮肤衍射图案确实发生了特定的变化，如下面所示，患者患有黑色素瘤和前列腺癌。 还研究了来自50名患者的样品的指甲衍射图案的变化。 在乳腺癌、结肠癌和阿尔茨海默病患者的衍射中发现了明显的变化，证实了早期的初步结果，但没有发现任何其他癌症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although huge advances have been made in the treatment of many neoplastic diseases over the last century, an early diagnosis is essential in most cases for a satisfactory prognosis. Unfortunately reliable diagnostic tests are not yet available for many such diseases. Amongst these are a number of very common, exceedingly aggressive cancers which are far too often terminal at first diagnosis. These Include melanoma, adeno lung and prostate cancer. 264 samples were investigated at the BioCAT Facility, Advanced Photon Source in March 2009 to determine whether any specific changes occurred in the skin adjacent to the cancer site or the nails for each of these cancers. Double-blinded full punch biopsies of skin were used for the skin experiments. Our results confirmed that specific changes did occur in the diffraction pattern of skin for melanoma, adeno lung and prostate cancers as illustrated below for a case where the patient had both melanoma and prostate cancer. Changes in the diffraction pattern for fingernails were also investigated for samples from 50 patients. Clear changes were noted in the diffraction for patients with breast cancer, colon cancer and Alzheimer's' disease confirming earlier preliminary results, but not with any other cancers..