CHANGES IN HAIR W/ DISEASE: CANCER IMPLICATION

我们最近报告(James等人，1999，头发作为诊断工具 治疗乳腺癌。《自然》328：33-34)非常激动人心的结果 在BioCAT光束线上进行的部分实验证明 乳腺癌的发生与外观的相关性研究 从头发中提取的纤维衍射图的其他特征 这些人。这些特征似乎与 毛发中的膜状成分。目前正在进行研究，以确定 这些变化的确切性质以及它们与 乳腺癌的各种类型和发展阶段 疾病。这些发现表明，相对 一种廉价、方便、无创的早期筛查方法 乳腺癌的检测。在皮肤上也发现了类似的发现 在体内某处存在恶性肿瘤的情况下进行的活检 胎儿胶原亚型在成人中的表达 皮肤。后一项研究结果已提交发表。 角蛋白和胶原形成复杂的结构，具有非常弱的 绕射特征。这些研究从罚款中受益匪浅 Focus(它增加了模式的信息含量)和 高流量(可显著增加吞吐量)由 BioCAT ID行。

We recently reported (James et al,1999, Hair as a Diagnostic Tool for Breast Cancer. Nature 328:33-34) very exciting results of experiments performed partly on the BioCAT beamline that demonstrated a correlation between the presence of breast cancer and the appearance of additional features in fiber diffraction patterns from hair from these individuals. These features appear to be associated with membranous components in the hair. Studies are underway to determine the exact nature of these changes and to see how they relate to various types of breast cancers and stage of development of the disease. These findings indicate the potential for a relatively cheap, convenient and non-invasive screening method for the early detection of breast cancer. Similar findings have been found for skin biopsies where the presence of malignancy somewhere in the body is indicated by expression of fetal isoforms of collagen in the adult skin. These latter results have been submitted for publication. Keratin and collagen form complex structures with very weakly diffracting features. These studies benefited greatly from the fine focus (which increases the information content of patterns) and the high flux (which dramatically increases throughput) provided by the BioCAT ID line.