CHANGES IN HAIR W/ DISEASE: CANCER IMPLICATION

头发随疾病的变化：癌症的影响

• 批准号: 6316847
• 负责人: VERONICA JAMES
• 金额: $ 3.86万
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6316847
• 关键词: biomedical resource; connective tissue; human tissue; neoplasm /cancer; structural biology

We recently reported (James et al,1999, Hair as a Diagnostic Tool for Breast Cancer. Nature 328:33-34) very exciting results of experiments performed partly on the BioCAT beamline that demonstrated a correlation between the presence of breast cancer and the appearance of additional features in fiber diffraction patterns from hair from these individuals. These features appear to be associated with membranous components in the hair. Studies are underway to determine the exact nature of these changes and to see how they relate to various types of breast cancers and stage of development of the disease. These findings indicate the potential for a relatively cheap, convenient and non-invasive screening method for the early detection of breast cancer. Similar findings have been found for skin biopsies where the presence of malignancy somewhere in the body is indicated by expression of fetal isoforms of collagen in the adult skin. These latter results have been submitted for publication. Keratin and collagen form complex structures with very weakly diffracting features. These studies benefited greatly from the fine focus (which increases the information content of patterns) and the high flux (which dramatically increases throughput) provided by the BioCAT ID line.

我们最近报道（James等，1999，毛发作为诊断工具 治疗乳腺癌 自然328：33-34）非常令人兴奋的结果 部分实验是在BioCAT光束线上进行的， 乳腺癌的存在与其外观之间的相关性 的纤维衍射图案的其他功能， 这些人。 这些特征似乎与 毛发中的膜状成分。 研究正在进行中，以确定 这些变化的确切性质，看看它们如何与 不同类型的乳腺癌和乳腺癌的发展阶段 疾病 这些发现表明，相对而言， 廉价、方便、无创的早期筛查方法 乳腺癌的检测。 皮肤也有类似的发现 活检，其中存在恶性肿瘤的地方，在身体是 由成人中胶原的胎儿同种型的表达指示 皮肤 这些结果已提交出版。 角蛋白和胶原蛋白形成复杂的结构， 衍射特征 这些研究从罚款中受益匪浅 焦点（增加模式的信息内容）和 高通量（这大大增加了吞吐量）提供的 BioCAT ID线。