MR SPECTROSCOPY OF RENAL MASSES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究最初是在R21 CA89671-01下资助的，MRS是由Pamela Nurenberg博士持有的NCI赠款，用于腹部肿瘤及周围组织的研究。用魔角旋转高分辨1H核磁共振仪对肾肿瘤及其周围正常组织进行了分析，并对高氯酸和氯仿甲醇提取物进行了1H核磁共振分析。尽管纽伦堡医生已经转到了不同的机构，但与泌尿外科的杰夫·卡德杜医生的合作仍在继续。在美国，每年大约有31,000例肾透明细胞癌(RCC)。由于医学成像工具的使用越来越多，在躯干成像过程中，由于其他医学原因，经常会发现潜在的RCC肿块。转移性肾癌的5年生存率不到10%。因此，对于小的、实质性的、非脂肪性肾肿块，最常见的推荐治疗方法是部分或全部肾切除。不幸的是，被切除的肿瘤中多达30%被证明是良性的。射频消融是一种微创技术，包括在肾肿块内插入一个小探头，然后用射频照射以破坏周围组织。目前，介入后活检(约1年后)用于确定手术是否成功。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research was initially funded under R21 CA89671-01, MRS of Tumors and Surrounding Tissue in the Abdomen, an NCI grant held by Dr. Pamela Nurenberg. Excised tissue, from renal tumors and the surrounding healthy tissue, was analyzed by magic angle spinning high resolution 1H NMR of the neat tissue and 1H NMR of the perchloric acid and chloroform methanol extracts. Although Dr. Nurenberg has moved to a different institution, the collaboration has continued with Dr. Jeff Caddedu in the Department of Urology. There are approximately 31,000 cases of renal clear cell carcinoma (RCC) per year in the United States. Due to the increased use of medical imaging tools, potential RCC masses often are found during imaging of the torso for other medical reasons. The 5-year survival rate for metastatic RCC is less than 10%. As a result, the most commonly recommended treatment of small, solid, non-fatty renal masses is partial or total nephrectomy. Unfortunately, as many as 30% of the neoplasms that are removed prove to be benign. Radio-frequency (RF) ablation is a minimally invasive technique that involves insertion of a small probe into the renal mass followed by irradiation with RF to destroy the surrounding tissue. Currently, post intervention biopsies (~1 year later) are used to determine if the procedure was successful.