MR SPECTROSCOPY OF RENAL MASSES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究最初是在R21 CA 89671 -01下资助的，腹部肿瘤和周围组织的MRS，由Pamela Nurenberg博士持有的NCI基金。通过纯组织的魔角旋转高分辨率1H NMR以及高氯酸和氯仿甲醇提取物的1H NMR分析来自肾肿瘤和周围健康组织的切除组织。虽然Nurenberg博士已经搬到了另一个机构，但与泌尿科的Jeff Caddedu博士的合作仍在继续。在美国，每年大约有31，000例肾透明细胞癌（RCC）。由于医学成像工具的使用越来越多，潜在的RCC群众往往被发现在躯干成像的其他医疗原因。转移性肾细胞癌的5年生存率低于10%。因此，最常推荐的治疗小，实性，非脂肪肾肿块是部分或全肾切除术。不幸的是，多达30%的切除肿瘤被证明是良性的。射频（RF）消融是一种微创技术，包括将小探针插入肾脏肿块，然后用RF照射以破坏周围组织。目前，介入后活检（约1年后）用于确定手术是否成功。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research was initially funded under R21 CA89671-01, MRS of Tumors and Surrounding Tissue in the Abdomen, an NCI grant held by Dr. Pamela Nurenberg. Excised tissue, from renal tumors and the surrounding healthy tissue, was analyzed by magic angle spinning high resolution 1H NMR of the neat tissue and 1H NMR of the perchloric acid and chloroform methanol extracts. Although Dr. Nurenberg has moved to a different institution, the collaboration has continued with Dr. Jeff Caddedu in the Department of Urology. There are approximately 31,000 cases of renal clear cell carcinoma (RCC) per year in the United States. Due to the increased use of medical imaging tools, potential RCC masses often are found during imaging of the torso for other medical reasons. The 5-year survival rate for metastatic RCC is less than 10%. As a result, the most commonly recommended treatment of small, solid, non-fatty renal masses is partial or total nephrectomy. Unfortunately, as many as 30% of the neoplasms that are removed prove to be benign. Radio-frequency (RF) ablation is a minimally invasive technique that involves insertion of a small probe into the renal mass followed by irradiation with RF to destroy the surrounding tissue. Currently, post intervention biopsies (~1 year later) are used to determine if the procedure was successful.