RETROSPECTIVE QUALITY ASSESSMENT OF FMRI DATA

FMRI 数据的回顾性质量评估

• 批准号: 7723801
• 负责人: MARK A ELLIOTT
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723801
• 关键词: Brain region; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Data Quality; Detection; Disease; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Intervention; Lead; Magnetic Resonance Imaging; Maintenance; Manufacturer Name; Noise; Performance; Research; Research Personnel; Resources; Signal Transduction; Source; Stimulus; Time; United States National Institutes of Health; comparison group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Functional magnetic resonance imaging (fMRI) is a specialized application of MRI which places additional demands on scanner performance and stability compared to routine clinical studies. Since fMRI attempts to identify brain regions activated in the presence of particular stimuli or tasks, instabilities or excessive noise in the MRI signal can lead to either false positive or negative detection of activation. When applied to group comparisons as is commonly the case in the study of disease or pharmacological interventions, changes in data quality over time can be misinterpreted as differences between groups. The requirements for fMRI generally exceed the specifications covered by commercial manufacturer quality assessment (QA) and preventative maintenance.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 功能性磁共振成像（fMRI）是MRI的一种专门应用， 与常规临床研究相比，对扫描仪性能和稳定性的额外要求。 由于功能磁共振成像试图识别大脑区域在特定刺激或 任务，MRI信号中的不稳定性或过度噪声可能导致假阳性或 阴性激活检测。当应用于组比较时，通常情况下 在疾病或药物干预的研究中，数据质量随时间的变化可以 被误解为群体之间的差异。功能磁共振成像的要求通常超过 商业制造商质量评估（QA）涵盖的质量标准，以及 预防性维护。