REAL-TIME FMRI WITH SINGLE VOXEL SPECTROSCOPY AT 7 TESLA

7 特斯拉单体素光谱实时 FMRI

• 批准号: 8361991
• 负责人: MARK A ELLIOTT
• 金额: $ 2.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361991
• 关键词: Biofeedback; Brain; Brain imaging; Discipline; Evaluation; Feedback; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Image; Magnetic Resonance; National Center for Research Resources; Neurologic; Neurons; Performance; Population; Principal Investigator; RF coil; Research; Research Infrastructure; Resources; Signal Transduction; Source; Spectrum Analysis; Speed; Time; United States National Institutes of Health; Water; base; comparison group; cost; image reconstruction; interest; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Functional magnetic resonance imaging (fMRI) is widely used in a variety of disciplines for evaluation and localization of neurological activity in the human brain. The majority of applications produce functional brain images post hoc, which can then be analyzed at the subject level, or propagated to group comparisons between subject populations. Recent improvements in scanner performance, RF coil sensitivity and image reconstruction speed have enabled the application of fMRI to real-time applications, in which neuronal activity can be self-modulated using bio-feedback approaches. Initial applications of real-time fMRI (rtfMRI) have used image based approaches, with a pre-selected region-of-interest (ROI) used to generate the feedback signal. We have demonstrated the use of single-voxel spectroscopy (SVS) to produce rtfMRI based biofeedback from the spectroscopic water signal within a similar ROI.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 功能磁共振成像（fMRI）被广泛用于多种学科中，用于评估和定位人脑中神经学活性。大多数应用程序产生了事后的功能性脑图像，然后可以在受试者水平上分析，或者在受试者人群之间进行分组比较。扫描仪性能，RF线圈灵敏度和图像重建速度的最新改进使fMRI应用于实时应用程序，在这种应用程序中，可以使用Bio Feptback方法进行神经元活动。实时fMRI（RTFMRI）的初始应用已使用基于图像的方法，并使用预选的利益区域（ROI）用于生成反馈信号。我们已经证明了使用单素光谱法（SVS）在类似ROI内从光谱水信号中产生基于RTFMRI的生物反馈。