REAL-TIME FMRI WITH SINGLE VOXEL SPECTROSCOPY AT 7 TESLA

7 特斯拉单体素光谱实时 FMRI

• 批准号: 8361991
• 负责人: MARK A ELLIOTT
• 金额: $ 2.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361991
• 关键词: Biofeedback; Brain; Brain imaging; Discipline; Evaluation; Feedback; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Image; Magnetic Resonance; National Center for Research Resources; Neurologic; Neurons; Performance; Population; Principal Investigator; RF coil; Research; Research Infrastructure; Resources; Signal Transduction; Source; Spectrum Analysis; Speed; Time; United States National Institutes of Health; Water; base; comparison group; cost; image reconstruction; interest; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Functional magnetic resonance imaging (fMRI) is widely used in a variety of disciplines for evaluation and localization of neurological activity in the human brain. The majority of applications produce functional brain images post hoc, which can then be analyzed at the subject level, or propagated to group comparisons between subject populations. Recent improvements in scanner performance, RF coil sensitivity and image reconstruction speed have enabled the application of fMRI to real-time applications, in which neuronal activity can be self-modulated using bio-feedback approaches. Initial applications of real-time fMRI (rtfMRI) have used image based approaches, with a pre-selected region-of-interest (ROI) used to generate the feedback signal. We have demonstrated the use of single-voxel spectroscopy (SVS) to produce rtfMRI based biofeedback from the spectroscopic water signal within a similar ROI.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 功能性磁共振成像（fMRI）被广泛应用于各种学科，用于评估和定位人脑中的神经活动。大多数应用程序事后生成功能性大脑图像，然后可以在受试者级别进行分析，或传播到受试者人群之间的组比较。最近在扫描仪性能、RF线圈灵敏度和图像重建速度方面的改进使得fMRI能够应用于实时应用，其中神经元活动可以使用生物反馈方法进行自调制。实时功能磁共振成像（rtfMRI）的最初应用已经使用基于图像的方法，其中预先选择的感兴趣区域（ROI）用于生成反馈信号。我们已经证明了使用单体素光谱（SVS），以产生rtfMRI为基础的生物反馈，从光谱水信号在一个类似的ROI。