REAL-TIME FMRI WITH SINGLE VOXEL SPECTROSCOPY AT 7 TESLA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 功能磁共振成像(FMRI)被广泛应用于各种学科中，用于评估和定位人脑的神经活动。大多数应用程序生成特定的功能脑图像，然后可以在受试者级别进行分析，或者传播到受试者群体之间的组比较。最近在扫描仪性能、射频线圈灵敏度和图像重建速度方面的改进使fMRI能够应用于实时应用，其中神经元活动可以使用生物反馈方法进行自我调节。实时功能磁共振成像(RtfMRI)的最初应用使用了基于图像的方法，使用预先选择的感兴趣区域(ROI)来产生反馈信号。我们已经演示了使用单体素光谱学(SVS)从相似ROI内的光谱水信号产生基于rtfMRI的生物反馈。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Functional magnetic resonance imaging (fMRI) is widely used in a variety of disciplines for evaluation and localization of neurological activity in the human brain. The majority of applications produce functional brain images post hoc, which can then be analyzed at the subject level, or propagated to group comparisons between subject populations. Recent improvements in scanner performance, RF coil sensitivity and image reconstruction speed have enabled the application of fMRI to real-time applications, in which neuronal activity can be self-modulated using bio-feedback approaches. Initial applications of real-time fMRI (rtfMRI) have used image based approaches, with a pre-selected region-of-interest (ROI) used to generate the feedback signal. We have demonstrated the use of single-voxel spectroscopy (SVS) to produce rtfMRI based biofeedback from the spectroscopic water signal within a similar ROI.