INVENTION DISCLOSURES - CENTER FOR IN VIVO MICROSCOPY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This reporting period, 2 invention disclosures were submitted to the Duke Office of Science and Technology: 12/2007: Cristian T. Badea, Samuel Johnston, G. Allan Johnson: Geometric Calibration Procedure for the Combination of Projection Images Acquired with Multiple Imaging Chains in a Single Tomographic Reconstruction We have presented here the first geometric calibration method suitable for a dual or multipel micro-CT system. The same technique can be used for more than two imaging chains. We are not aware of other published prior work on this subject. Since our method involves the geometric calibration of each individual chain, we could only compare part of our results with the previous work 5. Although we partially use the same formulas as Yang et al.5to initially estimate five of the geometric parameters, our method for single chain show advantages due to added refinement based on optimization step. The optimization based refinements improve the quality of reconstruction. Our results demonstrate that we also find accurate and precise values for the dual system parameters including the ¿z and a . 12/2007: G. Allan Johnson, Ph.D., Gabriel Howles-Banerji, Kristin Frinkley, Kathy Nightingale, Ph.D., Mark Palmeri, M.D., Ph.D.: Active staining for in vivo MR imaging in the brain Developed, implemented, and tested the methods for opening the blood-brain barrier and active staining. Provided insights into ultrasonic mechanisms of method. We describe a method for active staining to enhance the MR signal in the brain of live animals, i.e., in vivo contrast-enhanced brain imaging. The active staining method can be used to provide substantial increase in spatial resolutionmore than 5X greater than what has been seen previously. The same method can be used with specific probes and experimental protocols to provide quantitative localized measure of neuronal activity in the live rodent: functional MR imaging of the mouse or rat brain, again at spatial resolution substantially greater than has been demonstrated previously. Finally, with suitable probes and protocols, the method promises to help define the density of specific molecular targets in the brain in combination with very high-resolution 3D in vivo anatomic definition.