CRYSTAL STRUCTURE OF MEND

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 (1R，6R)-2-Succinyl-6-hydroxy-2，4-cyclohexadiene-1-carboxylate合成酶，又称MEND，参与了维生素K2的生物合成途径。该酶是ThDP依赖酶超家族的一部分，但它是已知的唯一一种催化不饱和羧酸盐的α-碳与ThDP加合物进行Stetter样的1，4-加成的酶。该酶的晶体结构对阐明该重要酶的作用机制具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (1R,6R)-2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) synthase, also called MenD, participates in the menaquinone (Vitamin K2) biosynthetic pathway. The enzyme is a part of the superfamily of ThDP-dependent enzymes, however it is the only enzyme known to catalyze a Stetter-like 1,4-addition of a ThDP adduct to the alpha-carbon of an unsaturated carboxylate. The crystal structure of this enzyme will be important for clarifying the mechanism of this important enzyme.