CRYSTAL STRUCTURE OF UDP-GALACTOPYRANOSE MUTASE FROM EUKARYOTIC PATHOGENS

真核病原体的 UDP-吡喃半乳糖变位酶的晶体结构

• 批准号: 8169229
• 负责人: DAVID A SANDERS
• 金额: $ 0.35万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169229
• 关键词: African Trypanosomiasis; Antibiotics; Aspergillosis; Aspergillus; Cell Wall; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; Disease; Enzymes; Eukaryota; Funding; Galactose; Grant; Human; Institution; Leishmania; Leishmaniasis; Mutase; Research; Research Personnel; Resources; Source; Structure; UDP-galactopyranose mutase; United States National Institutes of Health; World Health; pathogen; sugar; uridine diphosphate galactofuranose

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infectious diseases are a major world health problem and developing new antibiotics remains a critical field of research. Eukaryotic pathogens are less well understood than bacterial ones, but infect hundreds of millions of people world-wide. These diseases include leishmaniasis, Chaga's disease, African sleeping sickness and invasive aspergillosis. Eukaryotic pathogens are difficult to develop antibiotics against because they are fairly similar to humans. A potential target is UDP-galactopyranose mutase (UGM), which catalyzes the interconversion of UDP galactopyranose (UDP Galp; 6 membered ring) and UDP-galactofuranose (UDP Galf; 5 membered ring). UDP Galf is the precursor for galactofuranose (Galf) sugar residues found in cell wall components. We are currently studying the structure-function of this enzyme from the pathogenic eukaryotes Leishmania and Aspergillus.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 传染病是一个主要的世界性健康问题，开发新的抗生素仍然是一个关键的研究领域。真核病原体比细菌病原体了解得更少，但在世界各地感染着数亿人。这些疾病包括利什曼病、查加氏病、非洲昏睡病和侵袭性曲霉病。真核病原体很难开发出针对它们的抗生素，因为它们与人类非常相似。一个潜在的靶点是UDP-半乳糖变位酶(UGM)，它催化UDP-半乳糖(UDP Galp；6元环)和UDP-半乳呋喃糖(UDP Galf；5元环)的相互转化。UDP Galf是细胞壁成分中发现的半乳呋喃糖(Galf)糖残留物的前体。我们目前正在研究致病真核生物利什曼原虫和曲霉的这种酶的结构和功能。