RNA SPLICING ENDONUCLEASE IN COMPLEX WITH ITS RNA SUBSTRATE
RNA SPLICING ENDONUCLEASE IN COMPLEX WITH ITS RNA SUBSTRATE
批准号:
7721259
负责人:
Hong Li
金额:
$0.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-05-15 至 2009-03-31
关键词:
BindingCleaved cellComplexComputer Retrieval of Information on Scientific Projects DatabaseExcisionFunctional RNAFundingGrantInstitutionIntronsObject AttachmentPrecursor RNAProtein BiosynthesisRNARNA SplicingResearchResearch PersonnelResourcesSourceStructureUnited States National Institutes of Healthendonucleaseendoribonucleasephosphodiester
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
RNA剪接内切酶在去除内含子的过程中裂解折叠的前体RNA中的两个磷酸二酯键,产生蛋白质合成所需的功能RNA。目前还没有已知的结构与含有不同RNA基序的RNA底物结合的RNA内切酶。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The RNA splicing endonuclease cleaves two phosphodiester bonds within folded precursor RNAs during intron removal, producing the functional RNAs required for protein synthesis. There is currently no known structure of any RNA endonuclease bound with RNA substrate containing a distinct RNA motif.
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