Research Programs-Gene Regulation and Functional Genomics

研究项目-基因调控与功能基因组学

• 批准号: 7513245
• 负责人: Jeffrey Sklar
• 金额: $ 2.16万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-09 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7513245
• 关键词: Affect; Area; Behavior; Blood; Blood specimen; Cancer Center; Cancer Patient; Caring; Cell Cycle; Cells; Charge; Chromatin; Chromatin Structure; Clinical; Collaborations; Community Clinical Oncology Program; Complement; Consult; DNA; DNA Repair; DNA Structure; Development; Diagnosis; Direct Costs; Epigenetic Process; Funding; Gene Expression; Gene Expression Regulation; Gene Structure; Genes; Genetic; Genetic Polymorphism; Genetic Programming; Genetic Transcription; Genome; Genomics; Goals; Grant; Group Meetings; Hereditary Malignant Neoplasm; Human; Human Genome; Individual; Inherited; Institution; Investigation; Joints; Knowledge; Leadership; Link; Malignant Neoplasms; Methodology; Methods; Molecular Analysis; Molecular Genetics; Molecular Virology; Numbers; Oncology Group; Paper; Patients; Pattern; Peer Review; Phenotype; Predisposition; Prevention; Process; Program Description; Protein Biosynthesis; Proteins; Publishing; Radiation therapy; Radiobiology; Research; Screening for cancer; Series; Signal Pathway; Signal Transduction; Stem cells; Structure; Support Groups; Universities; Variant; base; cancer genetics; cancer risk; cancer therapy; cell transformation; cost; design; functional genomics; genome-wide analysis; improved; interest; medical schools; member; method development; molecular oncology; neoplastic; neoplastic cell; programs; technology development; tumor; tumor progression

The Program in Gene Regulation and Functional Genomics (GRFGP) is derived from the former Molecular Oncology Program (MOP) which was renamed to reflect a more sharpened focus. The reorganization reflects the profound developments that have occurred in the molecular genetics of cancer, as well as in the broader field of genomics, since the last competitive renewal of this grant. Under the joint leadership of Dr. Jeffrey Sklar and Dr. Sherman Weissman (former co-Leader of MOP), the GRFGP is designed to promote (1) research into the mechanisms and effects of gene expression relevant to the neoplastic phenotype, and (2) the investigation of cancer-associated broad-based structural and functional features of the human genome. These two aspects of the GRFGP cover the study of individual genes that contribute to the development and progression of cancer as well as the analysis of genome-wide gene expression, chromatin structure, and regulatory factors that characterize or control the neoplastic state. Furthermore, the goals of the research encompassed by this program include the development of methods to better elucidate and analyze the changes in genes, gene expression, and DNA related to cancer. Finally, this program is interested in both the biologic processes underlying cancer and the application of information about those processes to the improved prevention, diagnosis, and treatment of cancer. By focusing predominantly on the molecular analysis of sporadic cancers, the GRFGP complements the activities of the Cancer Genetics Program, which is charged with the identification and analysis of genes responsible for hereditary predisposition to cancer. The two Programs engage in significant collaborations, particularly in the area of technology development. The goals of the GRFGP are accomplished through joint sponsorship of the Molecular Virology and Oncology group meetings, major participation in the Stem Cell weekly group meetings, organization of the weekly Genetics Seminar series, institution of Pilot Grant program to stimulate programmatically-oriented research in cancer, as well as by facilitating collaboration between members within the program and other Cancer Center programs. The GRFGP consists of 20 independent but interactive members belonging to eight departments of the Medical School or University. Total peer-reviewed funding support of this group is approximately $4.7 million direct costs annually ($7.5 million total costs), of which just under $1 million direct costs ($1.4 total costs) come from NCI. Total direct funding is $4,79 million ($7.65 million total costs). During the previous grant period, members of this program published 208 cancer-related papers, of which 5.3% were intraprogrammatic and 15.9% inter-programmatic

基因调控和功能基因组学项目（GRFGP）源自前分子生物学项目 肿瘤学计划（MOP）已更名，以反映更明确的重点。重组 反映了癌症分子遗传学以及癌症领域的深刻发展 自上次竞争性更新该资助以来，基因组学领域更加广泛。在博士的共同领导下 Jeffrey Sklar 和 Sherman Weissman 博士（MOP 前联合领导人）表示，GRFGP 旨在促进 (1) 研究与肿瘤表型相关的基因表达的机制和影响，以及 (2) 人类与癌症相关的广泛结构和功能特征的研究 基因组。 GRFGP 的这两个方面涵盖了对有助于 癌症的发生和进展以及全基因组基因表达、染色质的分析 结构和表征或控制肿瘤状态的调节因素。此外，目标 该计划所涵盖的研究包括开发方法以更好地阐明和 分析与癌症相关的基因、基因表达和 DNA 的变化。最后这个程序是 对癌症的生物学过程以及相关信息的应用感兴趣 改进癌症的预防、诊断和治疗的过程。通过主要关注 散发性癌症的分子分析，GRFGP 补充了癌症遗传学的活动 程序，负责识别和分析负责遗传的基因 癌症倾向。这两个计划进行了重要的合作，特别是在以下领域： 技术开发。 GRFGP 的目标是通过以下机构的联合赞助来实现的： 分子病毒学和肿瘤学小组会议，主要参加干细胞每周小组 会议、组织每周遗传学研讨会系列、设立试点资助计划以刺激 以计划为导向的癌症研究，以及促进成员之间的合作 在该计划和其他癌症中心计划内。 GRFGP 由 20 名独立但互动的成员组成，分属于该组织的八个部门 医学院或大学。该小组经过同行评审的资助总额约为 470 万美元 每年直接成本（总成本 750 万美元），其中直接成本略低于 100 万美元（总成本 1.4 美元） 来自 NCI。直接资助总额为 479 万美元（总成本 765 万美元）。在上一次补助期间 期间，该计划成员发表了 208 篇癌症相关论文，其中 5.3% 为计划内论文 15.9% 为跨项目